Bin Zhang, Wei Kian Sim, Tang-Long Shen, Sai Kiang Lim
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引用次数: 0
摘要
细胞外囊泡(EVs)是大多数细胞释放的微小脂质膜结合结构。它们通过向受体细胞输送生物活性货物并引发细胞和生物反应,在促进细胞间通信方面发挥着重要作用。作为原生或工程外泌体,EVs 具有巨大的治疗应用潜力。原生外泌体是由细胞自然释放的,外泌体或分泌外泌体的细胞都没有经过任何修饰。与此相反,工程外泌体则是在分泌后或通过分泌细胞的基因工程故意改变其成分。在这里,我们提出,显示病原体蛋白的工程外泌体可作为脂质纳米粒子(LNP)-mRNA 疫苗的理想替代品。通过利用其独特的特性,这些工程化 EV 有可能克服 LNP-mRNA 疫苗的某些局限性。
Engineered EVs with pathogen proteins: promising vaccine alternatives to LNP-mRNA vaccines
Extracellular vesicles (EVs) are tiny, lipid membrane-bound structures that are released by most cells. They play a vital role in facilitating intercellular communication by delivering bioactive cargoes to recipient cells and triggering cellular as well as biological responses. EVs have enormous potential for therapeutic applications as native or engineered exosomes. Native EVs are naturally released by cells without undergoing any modifications to either the exosomes or the cells that secrete them. In contrast, engineered EVs have been deliberately modified post-secretion or through genetic engineering of the secreting cells to alter their composition. Here we propose that engineered EVs displaying pathogen proteins could serve as promising alternatives to lipid nanoparticle (LNP)-mRNA vaccines. By leveraging their unique characteristics, these engineered EVs have the potential to overcome certain limitations associated with LNP-mRNA vaccines.
期刊介绍:
The Journal of Biomedical Science is an open access, peer-reviewed journal that focuses on fundamental and molecular aspects of basic medical sciences. It emphasizes molecular studies of biomedical problems and mechanisms. The National Science and Technology Council (NSTC), Taiwan supports the journal and covers the publication costs for accepted articles. The journal aims to provide an international platform for interdisciplinary discussions and contribute to the advancement of medicine. It benefits both readers and authors by accelerating the dissemination of research information and providing maximum access to scholarly communication. All articles published in the Journal of Biomedical Science are included in various databases such as Biological Abstracts, BIOSIS, CABI, CAS, Citebase, Current contents, DOAJ, Embase, EmBiology, and Global Health, among others.