全面评述作为靶向给药策略的 Niosomes:制药和草药化妆品应用。

Sakshi Saharawat, Sushma Verma
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引用次数: 0

摘要

Niosomes 是一种新开发的自组装囊状转运体,可将药物集中输送到特定部位,提高药物在体内的可用性并延长疗效。iosome 的发现提高了药物的治疗效果,同时也减少了不良反应。本文旨在集中讨论全球范围内对niosomal制剂使用的增长情况。本综述从透彻的角度介绍了迄今为止对含膜制剂的研究,包括其类别和生产技术、在药物运输中的意义以及在化妆品中的使用。详尽的文献综述显示,人们对开发纳米载体用于药物输送给予了广泛关注,因为纳米载体在实现向患处靶向输送的同时还能保护邻近的健康组织,具有巨大的潜力。许多评论和研究论文的发表表明了科学家们对纳米载体的兴趣。具有抗氧化、抗生素、消炎、伤口愈合、抗痤疮和美白功效的植物成分也被封装到 niosome 中。由于其灵活性,可以加入各种治疗剂,包括小分子、蛋白质和肽,因此可用于不同类型的药物。可以用配体对 Niosomes 进行修饰,增强其靶向能力。非离子囊泡是由水合非离子表面活性剂、胆固醇或两亲化合物自组装而成的囊泡纳米载体,具有灵活的给药机制,可用于透皮给药和脑靶向给药等综合应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Comprehensive Review on Niosomes as a Strategy in Targeted Drug Delivery: Pharmaceutical, and Herbal Cosmetic Applications.

Niosomes are newly developed, self-assembling sac-like transporters that deliver medication at a specific site in a focused manner, increasing availability in the body and prolonging healing effects. Niosome discovery has increased drugs' therapeutic effectiveness while also reducing adverse effects. This article aims to concentrate on the increase in the worldwide utilization of niosomal formulation. This overview presents a thorough perspective of niosomal investigation up until now, encompassing categories and production techniques, their significance in pharmaceutical transportation, and cosmetic use. The thorough literature review revealed that extensive attention has been given to developing nanocarriers for drug delivery as they hold immense endeavor to attain targeted delivery to the affected area simultaneously shielding the adjacent healthy tissue. Many reviews and research papers have been published that demonstrate the interest of scientists in niosomes. Phytoconstituents, which possess antioxidant, antibiotic, anti-inflammatory, wound healing, anti-acne, and skin whitening properties, are also encapsulated into niosome. Their flexibility allows for the incorporation of various therapeutic agents, including small molecules, proteins, and peptides making them adaptable for different types of drugs. Niosomes can be modified with ligands, enhancing their targeting capabilities. A flexible drug delivery mechanism provided by non-ionic vesicles, which are self-assembling vesicular nano-carriers created from hydrating non-ionic surfactant, cholesterol, or amphiphilic compounds along comprehensive applications such as transdermal and brain-targeted delivery.

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