一名急性淋巴细胞白血病(ALL)患儿因阿曼巴斯迪波洛斯菌引起的播散性巴斯迪波洛斯菌病。病例报告与文献综述。

IF 3.6 3区 生物学 Q2 MYCOLOGY
Laila Al Yazidi, Sharifa Al Sinani, Badriya Al Adawi, Marwa Al Riyami, Yasser Wali, Abdulhakeem Al Rawas, Buthaina Al Musalhi, Jacques F Meis, Saif Al Housni, Ahmed Al-Harrasi, Abdullah M S Al Hatmi
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引用次数: 0

摘要

巴氏菌病是由巴氏菌属引起的一种不常见的真菌感染。在免疫功能正常的儿童中,该病通常会引起皮肤感染,很少会影响胃肠道,而且该病极少发生传播。本研究报告了首例由阿曼巴斯迪波真菌引起的播散性巴斯迪波真菌病病例,患儿患有急性淋巴细胞白血病,尽管接受了手术和 L-AMB 及伏立康唑等抗真菌治疗,但仍因感染失控和多器官功能衰竭而死亡。查阅文献后发现,包括本病例在内,共有 76 个病例,其中大多数报告为侵袭性胃肠道感染。中位年龄为 4 岁(61 名男性和 15 名女性),这些儿童大多来自中东(80%),特别是沙特阿拉伯(45%)。大多数患者接受了全身抗真菌治疗(主要是伊曲康唑和两性霉素 B)。其中 25% 的患者接受了手术治疗,死亡率为 12%。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Disseminated Basidiobolomycosis Caused by Basidiobolus omanensis in a Child with Acute Lymphoblastic Leukemia (ALL). Case Report and Literature Review.

Disseminated Basidiobolomycosis Caused by Basidiobolus omanensis in a Child with Acute Lymphoblastic Leukemia (ALL). Case Report and Literature Review.

Basidiobolomycosis is an uncommon fungal infection caused by the genus Basidiobolus. In immunocompetent children, it usually causes cutaneous infection and rarely affects the gastrointestinal tract, and it is extremely rare for the disease to spread. The present study reports the first case of disseminated basidiobolomycosis caused by Basidiobolus omanensis in a child with acute lymphoblastic leukemia who died as a result of uncontrolled infection and multi-organ failure despite surgical and antifungal therapy with L-AMB and voriconazole. A review of the literature yielded 76 cases, including the current case with the majority of which were reported as invasive gastrointestinal infection. The median age was 4 years (61 male and 15 female) and the majority of these children were from the Middle East (80%), specifically Saudi Arabia (45%). Most patients were treated with systemic antifungal agents (mostly itraconazole and amphotericin B). Surgical intervention was done in 25% of these patients and the death rate was 12%.

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来源期刊
Mycopathologia
Mycopathologia 生物-真菌学
CiteScore
6.80
自引率
3.60%
发文量
76
审稿时长
3 months
期刊介绍: Mycopathologia is an official journal of the International Union of Microbiological Societies (IUMS). Mycopathologia was founded in 1938 with the mission to ‘diffuse the understanding of fungal diseases in man and animals among mycologists’. Many of the milestones discoveries in the field of medical mycology have been communicated through the pages of this journal. Mycopathologia covers a diverse, interdisciplinary range of topics that is unique in breadth and depth. The journal publishes peer-reviewed, original articles highlighting important developments concerning medically important fungi and fungal diseases. The journal highlights important developments in fungal systematics and taxonomy, laboratory diagnosis of fungal infections, antifungal drugs, clinical presentation and treatment, and epidemiology of fungal diseases globally. Timely opinion articles, mini-reviews, and other communications are usually invited at the discretion of the editorial board. Unique case reports highlighting unprecedented progress in the diagnosis and treatment of fungal infections, are published in every issue of the journal. MycopathologiaIMAGE is another regular feature for a brief clinical report of potential interest to a mixed audience of physicians and laboratory scientists. MycopathologiaGENOME is designed for the rapid publication of new genomes of human and animal pathogenic fungi using a checklist-based, standardized format.
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