趋化因子系统的起源、进化和分子多样性。

IF 3.3 2区 生物学 Q1 BIOLOGY
Life Science Alliance Pub Date : 2024-01-16 Print Date: 2024-03-01 DOI:10.26508/lsa.202302471
Alessandra Aleotti, Matthew Goulty, Clifton Lewis, Flaviano Giorgini, Roberto Feuda
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引用次数: 0

摘要

趋化因子信号通过趋化吸引在细胞迁移中发挥关键作用,例如在宿主防御过程中将白细胞吸引到感染部位。该系统由配体(通常在细胞外分泌的趋化因子)和靶细胞表面识别配体的趋化因子受体组成。一些非规范成分与该系统相互作用。其中包括各种分子,它们通常与典型成分具有一定程度的序列相似性,在某些情况下,它们还能与典型成分结合和/或调节细胞迁移。虽然脊椎动物谱系中已经描述了经典成分,但非经典成分的分布却不太清楚。典范成分和非典范成分之间关系的不确定性阻碍了我们对该系统进化的理解。我们使用了系统发生学方法,包括基因树与物种树的协调,来理清规范和非规范成分之间的关系,确定基因复制事件,并澄清该系统的起源。我们发现,不相关的配体组独立进化出了类似趋化因子的功能。我们发现了脊椎动物以外的非经典配体,如在泌尿脊索动物中发现的 TAFA "趋化因子"。与此相反,所有受体组都是脊椎动物特有的,而且除了 ACKR1 之外,所有受体组都起源于早期脊椎动物的共同祖先。配体和受体的拷贝数都是在有颌脊椎动物的基础上通过基因复制事件扩大的,随后的创新浪潮发生在多骨鱼和哺乳动物身上。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The origin, evolution, and molecular diversity of the chemokine system.

Chemokine signalling performs key functions in cell migration via chemoattraction, such as attracting leukocytes to the site of infection during host defence. The system consists of a ligand, the chemokine, usually secreted outside the cell, and a chemokine receptor on the surface of a target cell that recognises the ligand. Several noncanonical components interact with the system. These include a variety of molecules that usually share some degree of sequence similarity with canonical components and, in some cases, are known to bind to canonical components and/or to modulate cell migration. Whereas canonical components have been described in vertebrate lineages, the distribution of the noncanonical components is less clear. Uncertainty over the relationships between canonical and noncanonical components hampers our understanding of the evolution of the system. We used phylogenetic methods, including gene-tree to species-tree reconciliation, to untangle the relationships between canonical and noncanonical components, identify gene duplication events, and clarify the origin of the system. We found that unrelated ligand groups independently evolved chemokine-like functions. We found noncanonical ligands outside vertebrates, such as TAFA "chemokines" found in urochordates. In contrast, all receptor groups are vertebrate-specific and all-except ACKR1-originated from a common ancestor in early vertebrates. Both ligand and receptor copy numbers expanded through gene duplication events at the base of jawed vertebrates, with subsequent waves of innovation occurring in bony fish and mammals.

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来源期刊
Life Science Alliance
Life Science Alliance Agricultural and Biological Sciences-Plant Science
CiteScore
5.80
自引率
2.30%
发文量
241
审稿时长
10 weeks
期刊介绍: Life Science Alliance is a global, open-access, editorially independent, and peer-reviewed journal launched by an alliance of EMBO Press, Rockefeller University Press, and Cold Spring Harbor Laboratory Press. Life Science Alliance is committed to rapid, fair, and transparent publication of valuable research from across all areas in the life sciences.
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