对新生儿红斑狼疮体内反射共聚焦显微镜特征的初步评估

IF 3 3区医学 Q2 DERMATOLOGY

Dermatology Pub Date : 2024-01-01 Epub Date: 2024-01-16 DOI:10.1159/000536130

Ying Wang, Lixin Chen, Bei Qin, Xibo Gao, Qinfeng Li

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引用次数: 0

摘要

背景：新生儿红斑狼疮（NLE）是一种罕见的自身免疫性疾病，需要与新生儿湿疹、先天性梅毒和体癣相鉴别。反射共聚焦显微镜（RCM）是一种有用的无创诊断工具，已被用于评估多种炎症性皮肤病。本研究的目的是描述 NLE 的反射共聚焦显微镜特征。方法：研究纳入了 9 名 NLE 患者，所有患者都接受了反射共聚焦显微镜临床评估：结果：通过 RCM 可以观察到一些主要的 NLE 诊断特征：扩大的蜂窝状结构（7/9，78%），圆形至椭圆形的囊样结构（6/9，67%），正常的环状结构在真皮-表皮交界处完全或部分消失（9/9，100%），中折射率的粗纤维物质杂乱无章（8/9，89%），真皮中存在大量高折射率的圆形细胞（9/9，100%）：结论：RCM 可以显示 NLE 的主要关键诊断特征，是 NLE 的辅助诊断工具。

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Preliminary Evaluation of in vivo Reflectance Confocal Microscopy Features of Neonatal Lupus Erythematosus.

Introduction: Neonatal lupus erythematosus (NLE) is a rare autoimmune disease, which needs to be distinguished from eczema, congenital syphilis, and tinea corporis in newborns. Reflectance confocal microscopy (RCM) could be a helpful noninvasive diagnostic tool, which has been used to evaluate several inflammatory skin conditions. The aim of this study was to describe the RCM characteristics of NLE.

Methods: Eleven NLE patients were included in the study, and all patients were evaluated clinically with RCM. We also evaluated RCM images from 11 eczema patients as controls.

Results: Some major key diagnostic features of NLE can be observed by RCM: an enlarged honeycomb pattern (9/11, 81.8%), round-to-oval cyst-like structures were present (6/11, 54.5%), the normal ring-like structures were totally or partially obliterated (11/11, 100%) at the level of the dermo-epidermal junction, medium refractivity collagen fibers that were disorganized (10/11, 90.9%), numerous high refractivity round cells (11/11, 100%) in the dermis.

Conclusion: RCM allows the visualization of major key diagnostic features of NLE and serves as a complementary diagnostic tool for NLE.

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来源期刊

Dermatology 医学-皮肤病学

CiteScore

6.40

自引率

2.90%

发文量

审稿时长

1 months

期刊介绍： Published since 1893, ''Dermatology'' provides a worldwide survey of clinical and investigative dermatology. Original papers report clinical and laboratory findings. In order to inform readers of the implications of recent research, editorials and reviews prepared by invited, internationally recognized scientists are regularly featured. In addition to original papers, the journal publishes rapid communications, short communications, and letters to ''Dermatology''. ''Dermatology'' answers the complete information needs of practitioners concerned with progress in research related to skin, clinical dermatology and therapy. The journal enjoys a high scientific reputation with a continually increasing impact factor and an equally high circulation.