特应性皮炎严重程度与牛皮癣风险：一项基于全国人口的研究。

IF 3 3区医学 Q2 DERMATOLOGY

Dermatology Pub Date : 2024-01-01 Epub Date: 2024-01-16 DOI:10.1159/000536143

Hyun Ji Lee, Yong Jun Hong, Kyung Do Han, Ji Hyun Lee

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引用次数: 0

摘要

背景：随着对Th17/IL-23通路作用的研究日益受到重视，特应性皮炎（AD）与银屑病之间的关系也逐渐被阐明：评估特应性皮炎及其严重程度是否会影响银屑病的发病风险：这项基于人群的回顾性研究使用了 2009 年韩国国民健康保险服务-健康筛查队列的数据库。共纳入 3957922 名成年受试者，并观察至 2018 年。主要结果是新诊断的银屑病：调整可能的混杂因素后，在中位 8.11 ± 1.19 年的随访期间，与非 AD 组相比，中重度 AD 组的银屑病危险比（HR）最高（HR = 2.50；95% 置信区间（CI），2.40-2.61），其次是轻度 AD 组（HR = 2.31；95% CI，2.19-2.44）：局限性：很难使用索赔数据库来定义未标准化的注意力缺失症，也很难排除被误诊为注意力缺失症的患者：结论：与对照组相比，严重注意力缺失症患者患银屑病的风险增加，而且患银屑病的风险随注意力缺失症的严重程度而增加。这表明银屑病和注意力缺失症可能具有共同的炎症、免疫和遗传特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Atopic Dermatitis Severity and Risk for Psoriasis: A Nationwide Population-Based Study.

Introduction: As research on the role of the Th17/IL-23 pathway gains importance, the relationship between atopic dermatitis (AD) and psoriasis is becoming elucidated.

Objective: The objective of this study wasto evaluate whether AD and its severity affect the risk for psoriasis.

Methods: This retrospective population-based study used the database from the 2009 National Health Insurance Services-Health Screening Cohort in Korea. A total of 3,957,922 adult subjects were included and observed until 2018. The primary outcome was newly diagnosed psoriasis.

Results: After adjusting for possible confounding factors, the moderate-to-severe AD group had the highest hazard ratio (HR) for psoriasis (HR = 2.50; 95% confidence interval (CI), 2.40-2.61), followed by the mild AD group (HR = 2.31; 95% CI: 2.19-2.44) compared with the non-AD group during a median 8.11 ± 1.19 years of follow-up.

Limitations: It is difficult to define AD, which is not standardized, using a claims database and exclude patients who were misdiagnosed with AD.

Conclusion: Patients with severe AD showed an increased risk for psoriasis compared to controls, and the risk for psoriasis was increased according to AD severity. This suggests that psoriasis and AD could share inflammatory, immune, and genetic features.

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来源期刊

Dermatology 医学-皮肤病学

CiteScore

6.40

自引率

2.90%

发文量

审稿时长

1 months

期刊介绍： Published since 1893, ''Dermatology'' provides a worldwide survey of clinical and investigative dermatology. Original papers report clinical and laboratory findings. In order to inform readers of the implications of recent research, editorials and reviews prepared by invited, internationally recognized scientists are regularly featured. In addition to original papers, the journal publishes rapid communications, short communications, and letters to ''Dermatology''. ''Dermatology'' answers the complete information needs of practitioners concerned with progress in research related to skin, clinical dermatology and therapy. The journal enjoys a high scientific reputation with a continually increasing impact factor and an equally high circulation.