职业暴露于焊接烟尘导致膀胱癌、肾癌和前列腺癌的风险:系统回顾和荟萃分析。

IF 2.6 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Giulia Collatuzzo, Maha Hamdani, Paolo Boffetta
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引用次数: 0

摘要

背景:我们的目的是对接触焊接烟尘(WF)的工人患泌尿生殖系统癌症风险的队列研究进行荟萃分析:我们旨在对接触焊接烟尘(WF)的工人患泌尿生殖系统癌症风险的队列研究进行荟萃分析:我们按照 PRISMA 标准对发表在 Pubmed、Scopus 和 Embase 上的研究进行了系统回顾。两名研究人员选择了有关接触 WF 的队列研究。从 2582 篇文章中,纳入了 7 项非重叠研究。研究质量根据 CASP 进行评分。我们进行了随机效应荟萃分析,计算了GU癌症的总体相对风险(RR)和95%置信区间(CI),并按癌症、国家和质量评分进行了分层:我们纳入了七项研究,这些研究报告了包括前列腺癌、膀胱癌和肾癌(PC、BC 和 KC)在内的 GU 癌症的结果。GU癌的RR为1.19(95% CI = 1.07-1.32,16个风险估计值);PC为1.13(95% CI = 0.90-1.42,4个风险估计值);BC为1.26(95% CI = 0.98-1.60,7个风险估计值);KC为1.28(95% CI = 1.12-1.47,5个风险估计值)。所有荟萃分析均存在异质性(P 结论:荟萃分析表明,BC、KC 和 BC 均存在异质性:这项荟萃分析表明,接触 WF 的工人罹患 KC 和 BC 的风险增加,但罹患 PC 的风险没有增加。无法排除其他职业和非职业风险因素的干扰。数据不足以说明特定暴露环境的风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Risk of bladder, kidney and prostate cancer from occupational exposure to welding fumes: a systematic review and meta-analysis.

Background: Our aimed to conduct a meta-analysis of cohort studies on risk of genitourinary (GU) cancers in workers exposed to welding fumes (WF).

Methods: We performed a systematic review of studies published on Pubmed, Scopus and Embase following PRISMA criteria. Two researchers selected cohort studies on WF exposure. From 2582 articles, 7 non-overlapping studies were included. Quality of studies was scored according to CASP. We run a random effects meta-analysis to calculate the relative risk (RR) and 95% confidence intervals (CI) of GU cancer, overall and stratified by cancer, country, and quality score.

Results: We included seven studies reporting results on GU cancers, including prostate, bladder and kidney cancer (PC, BC, and KC). The RR was 1.19 (95% CI = 1.07-1.32, 16 risk estimates) for GU cancer; 1.13 (95% CI = 0.90-1.42, 4 risk estimates) for PC; 1.26 (95% CI = 0.98-1.60, 7 risk estimates) for BC and 1.28 (95% CI = 1.12-1.47, 5 risk estimates) for KC. Heterogeneity was present in all meta-analyses (p < 0.001). The increased risk was more pronounced in North American than in European studies (respectively, OR = 1.35, 95% CI = 1.18-1.55; OR = 1.13, 95% CI = 1.01-1.27 p heterogeneity = 0.03). There was no heterogeneity according to quality score (p = 0.4). Data were insufficient to investigate associations by industry or welding type. Publication bias for each cancer was excluded.

Conclusion: This meta-analysis suggests increased risk of KC and BC, but not of PC, in workers exposed to WF. Confounding by other occupational and non-occupational risk factors could not be excluded. Data were not adequate to address the risk of specific exposure circumstances.

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来源期刊
International Archives of Occupational and Environmental Health
International Archives of Occupational and Environmental Health 医学-公共卫生、环境卫生与职业卫生
CiteScore
5.60
自引率
6.70%
发文量
127
审稿时长
3 months
期刊介绍: International Archives of Occupational and Environmental Health publishes Editorials, Review Articles, Original Articles, and Letters to the Editor. It welcomes any manuscripts dealing with occupational or ambient environmental problems, with a special interest in research at the interface of occupational health and clinical medicine. The scope ranges from Biological Monitoring to Dermatology, from Fibers and Dust to Human Toxicology, from Nanomaterials and Ultra-fine Dust to Night- and Shift Work, from Psycho-mental Distress and Burnout to Vibrations. A complete list of topics can be found on the right-hand side under For authors and editors. In addition, all papers should be based on present-day standards and relate to: -Clinical and epidemiological studies on morbidity and mortality -Clinical epidemiological studies on the parameters relevant to the estimation of health risks -Human experimental studies on environmental health effects. Animal experiments are only acceptable if relevant to pathogenic aspects. -Methods for studying the topics mentioned above.
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