血液透析中体外循环的凝血：超越接触激活凝血

IF 2.8 3区医学 Q2 UROLOGY & NEPHROLOGY

Seminars in nephrology Pub Date : 2024-01-16 DOI:10.1016/j.semnephrol.2023.151473

Matthias M. Engelen, Peter Verhamme, Thomas Vanassche

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引用次数: 0

摘要

终末期肾病患者经常出现血栓并发症。血液透析虽然是挽救这些患者生命的一种治疗方法，但也会带来血栓性炎症环境。此外，由于凝血系统、血小板和免疫系统的不同激活机制之间的相互作用，体外血液透析回路本身也容易发生凝血。患者和机器的抗凝治疗经常会因出血而变得复杂。我们讨论了这一平衡过程中的重要因素，并介绍了针对血栓炎症的潜在策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Clotting of the Extracorporeal Circuit in Hemodialysis: Beyond Contact-Activated Coagulation

Thrombotic complications in patients with end-stage kidney disease are frequent. While being a lifesaving treatment for these patients, hemodialysis introduces a thromboinflammatory environment. Additionally, the extracorporeal hemodialysis circuit itself is prone to clotting because of an interaction between different activation mechanisms of the coagulation system, platelets, and the immune system. Anticoagulation of the patient and the machine is frequently complicated by bleeding. We discuss the factors important in this balancing act and touch on potential strategies that are on the horizon to target thromboinflammation.

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来源期刊

Seminars in nephrology 医学-泌尿学与肾脏学

CiteScore

5.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Seminars in Nephrology is a timely source for the publication of new concepts and research findings relevant to the clinical practice of nephrology. Each issue is an organized compendium of practical information that serves as a lasting reference for nephrologists, internists and physicians in training.