哺乳动物卵母细胞玻璃化:线粒体功能障碍的最新研究

IF 1.6 4区 生物学
Biopreservation and Biobanking Pub Date : 2024-10-01 Epub Date: 2024-01-16 DOI:10.1089/bio.2023.0062
Yixiao Zhu, Hongyu Liu, Lv Zheng, Yuwen Luo, Guizhen Zhou, Jun Li, Yunpeng Hou, Xiangwei Fu
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引用次数: 0

摘要

在动物育种和辅助生殖中,生殖细胞玻璃化技术无疑是不可或缺的。然而,伴随这项技术而来的问题,如卵母细胞能力下降和胚胎存活率相对较低,似乎是一个长期困惑我们的难题。作为细胞代谢的重要细胞器,线粒体在许多途径中发挥着关键作用。然而,大量证据表明,玻璃化处理会严重损害哺乳动物卵母细胞线粒体的功能。因此,在本文中,我们总结了目前卵母细胞玻璃化的进展,并特别概述了哺乳动物卵母细胞玻璃化后常见的线粒体异常以及随后的损伤级联。在现有文献的基础上,我们初步提出了线粒体功能障碍的潜在机制,并归纳了恢复线粒体功能的有效方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Vitrification of Mammalian Oocytes: Recent Studies on Mitochondrial Dysfunction.

Vitrification of reproductive cells is definitely essential and integral in animal breeding, as well as in assisted reproduction. However, issues accompanied with this technology such as decreased oocyte competency and relatively low embryo survival rates appear to be a tough conundrum that has long perplexed us. As significant organelles in cell metabolism, mitochondria play pivotal roles in numerous pathways. Nonetheless, extensive evidence has demonstrated that vitrification can seriously impair mitochondrial function in mammalian oocytes. Thus, in this article, we summarize the current progress in oocyte vitrification and particularly outline the common mitochondrial abnormalities alongside subsequent injury cascades seen in mammalian oocytes following vitrification. Based on existing literature, we tentatively come up with the potential mechanisms related to mitochondrial dysfunction and generalize efficacious ways which have been recommended to restore mitochondrial function.

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来源期刊
Biopreservation and Biobanking
Biopreservation and Biobanking Biochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology
自引率
12.50%
发文量
114
期刊介绍: Biopreservation and Biobanking is the first journal to provide a unifying forum for the peer-reviewed communication of recent advances in the emerging and evolving field of biospecimen procurement, processing, preservation and banking, distribution, and use. The Journal publishes a range of original articles focusing on current challenges and problems in biopreservation, and advances in methods to address these issues related to the processing of macromolecules, cells, and tissues for research. In a new section dedicated to Emerging Markets and Technologies, the Journal highlights the emergence of new markets and technologies that are either adopting or disrupting the biobank framework as they imprint on society. The solutions presented here are anticipated to help drive innovation within the biobank community. Biopreservation and Biobanking also explores the ethical, legal, and societal considerations surrounding biobanking and biorepository operation. Ideas and practical solutions relevant to improved quality, efficiency, and sustainability of repositories, and relating to their management, operation and oversight are discussed as well.
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