Toufik Abdul-Rahman, Wireko Andrew Awuah, Tatiana Mikhailova, Jacob Kalmanovich, Aashna Mehta, Jyi Cheng Ng, Megan Ariel Coghlan, Marija Zivcevska, Alexander J. Tedeschi, Emerson Costa de Oliveira, Akinchita Kumar, Emiliano Cantu-Herrera, Mykola Lyndin, Kateryna Sikora, Athanasios Alexiou, Anwar L. Bilgrami, Khalid Mohammed Al-Ghamdi, Asma Perveen, Marios Papadakis, Ghulam Md Ashraf
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引用次数: 0
摘要
阿尔茨海默病(AD)是一种多因素神经退行性病变,以认知功能退化、人格改变和行为转变为特征。由于激活了多种神经毒性通路,持续的脑损伤过程给治疗干预带来了巨大挑战。目前的药物干预疗效有限,而且副作用很大。在激活广泛的神经毒性过程之前,对疾病通路进行早期干预的方法有望减缓疾病症状的发展。姜黄素是世界上众多文化中传统医学不可或缺的组成部分,它作为一种有前景的抗多发性硬化症治疗方法引起了人们的兴趣。目前的研究表明,姜黄素因其强大的抗炎和抗氧化特性,可能对神经退行性病变具有治疗潜力。此外,姜黄素及其衍生物还表现出通过表观遗传机制调节细胞通路的能力。本文旨在提高人们对姜黄素神经保护特性的认识,这些特性可能会给注意力缺失症带来治疗益处。本文全面概述了姜黄素针对可能与 AD 有关的信号通路的神经保护功效,并总结了姜黄素在体内的生物学功效的最新证据。
Antioxidant, anti-inflammatory and epigenetic potential of curcumin in Alzheimer's disease
Alzheimer's disease (AD) constitutes a multifactorial neurodegenerative pathology characterized by cognitive deterioration, personality alterations, and behavioral shifts. The ongoing brain impairment process poses significant challenges for therapeutic interventions due to activating multiple neurotoxic pathways. Current pharmacological interventions have shown limited efficacy and are associated with significant side effects. Approaches focusing on the early interference with disease pathways, before activation of broad neurotoxic processes, could be promising to slow down symptomatic progression of the disease. Curcumin—an integral component of traditional medicine in numerous cultures worldwide—has garnered interest as a promising AD treatment. Current research indicates that curcumin may exhibit therapeutic potential in neurodegenerative pathologies, attributed to its potent anti-inflammatory and antioxidant properties. Additionally, curcumin and its derivatives have demonstrated an ability to modulate cellular pathways via epigenetic mechanisms. This article aims to raise awareness of the neuroprotective properties of curcuminoids that could provide therapeutic benefits in AD. The paper provides a comprehensive overview of the neuroprotective efficacy of curcumin against signaling pathways that could be involved in AD and summarizes recent evidence of the biological efficiency of curcumins in vivo.
期刊介绍:
BioFactors, a journal of the International Union of Biochemistry and Molecular Biology, is devoted to the rapid publication of highly significant original research articles and reviews in experimental biology in health and disease.
The word “biofactors” refers to the many compounds that regulate biological functions. Biological factors comprise many molecules produced or modified by living organisms, and present in many essential systems like the blood, the nervous or immunological systems. A non-exhaustive list of biological factors includes neurotransmitters, cytokines, chemokines, hormones, coagulation factors, transcription factors, signaling molecules, receptor ligands and many more. In the group of biofactors we can accommodate several classical molecules not synthetized in the body such as vitamins, micronutrients or essential trace elements.
In keeping with this unified view of biochemistry, BioFactors publishes research dealing with the identification of new substances and the elucidation of their functions at the biophysical, biochemical, cellular and human level as well as studies revealing novel functions of already known biofactors. The journal encourages the submission of studies that use biochemistry, biophysics, cell and molecular biology and/or cell signaling approaches.