猪和人心室的小梁数量不同,但总体积相似。

IF 2.3 4区 医学 Q1 ANATOMY & MORPHOLOGY
Clinical Anatomy Pub Date : 2024-01-13 DOI:10.1002/ca.24135
Bjarke Jensen, Daniela Salvatori, Jacobine Schouten, Veronique M. F. Meijborg, Henrik Lauridsen, Peter Agger
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引用次数: 0

摘要

心室管腔内有错综复杂的网状小梁。压实是一种发育过程,它被认为是通过将小梁添加到邻近的致密壁来减少小梁,从而使致密壁增大。猪是异种移植的理想心脏供体,与人相比,猪心室壁上的小梁更少。我们假设猪的小梁体积比人的小。从宏观上看,我们在 16 颗猪心中观察到,心室壁上的小梁数量少但体积大。仔细观察发现,在大的小梁凹陷处有大量微小的小梁,有几百个。这些小梁虽然很小,但仍然比胚胎小梁大,即使考虑到它们的数量,猪的小梁总数也比人少得多。根据高分辨率核磁共振成像对另外六颗猪心和六颗人心进行的容积测量显示,猪左心室的小梁差异不大(分别为 21.5% 和 22.8%),猪右心室的小梁也略少(分别为 42.1% 和 49.3%)。然后,我们对孕 14-35 天的 10 个猪胚胎心脏进行了容积分析。小梁层和致密层始终在生长,小梁间凹陷也在生长,这与压实所预测的情况相反。尽管如此,小梁层和致密层的比例还是发生了很大变化,这是因为它们的生长速度不同,而不是因为压实。总之,影响小梁形态的过程并不一定会影响小梁与致密心肌的比例,因此它们与压实是不同的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Trabeculations of the porcine and human cardiac ventricles are different in number but similar in total volume

Trabeculations of the porcine and human cardiac ventricles are different in number but similar in total volume

An intricate meshwork of trabeculations lines the luminal side of cardiac ventricles. Compaction, a developmental process, is thought to reduce trabeculations by adding them to the neighboring compact wall which is then enlarged. When pig, a plausible cardiac donor for xenotransplantation, is compared to human, the ventricular walls appear to have fewer trabeculations. We hypothesized the trabecular volume is proportionally smaller in pig than in human. Macroscopically, we observed in 16 pig hearts that the ventricular walls harbor few but large trabeculations. Close inspection revealed a high number of tiny trabeculations, a few hundred, within the recesses of the large trabeculations. While tiny, these were still larger than embryonic trabeculations and even when considering their number, the total tally of trabeculations in pig was much fewer than in human. Volumetrics based on high-resolution MRI of additional six pig hearts compared to six human hearts, revealed the left ventricles were not significantly differently trabeculated (21.5 versus 22.8%, respectively), and the porcine right ventricles were only slightly less trabeculated (42.1 vs 49.3%, respectively). We then analyzed volumetrically 10 pig embryonic hearts from gestational day 14–35. The trabecular and compact layer always grew, as did the intertrabecular recesses, in contrast to what compaction predicts. The proportions of the trabecular and compact layers changed substantially, nonetheless, due to differences in their growth rate rather than compaction. In conclusion, processes that affect the trabecular morphology do not necessarily affect the proportion of trabecular-to-compact myocardium and they are then distinct from compaction.

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来源期刊
Clinical Anatomy
Clinical Anatomy 医学-解剖学与形态学
CiteScore
5.50
自引率
12.50%
发文量
154
审稿时长
3 months
期刊介绍: Clinical Anatomy is the Official Journal of the American Association of Clinical Anatomists and the British Association of Clinical Anatomists. The goal of Clinical Anatomy is to provide a medium for the exchange of current information between anatomists and clinicians. This journal embraces anatomy in all its aspects as applied to medical practice. Furthermore, the journal assists physicians and other health care providers in keeping abreast of new methodologies for patient management and informs educators of new developments in clinical anatomy and teaching techniques. Clinical Anatomy publishes original and review articles of scientific, clinical, and educational interest. Papers covering the application of anatomic principles to the solution of clinical problems and/or the application of clinical observations to expand anatomic knowledge are welcomed.
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