药物相关性颌骨骨坏死的保守治疗和手术治疗效果比较:系统性综述》(Comparison of Effectiveness of Conservative and Surgical Treatment of Medication-Related Osteonecrosis of the Jaw: a Systematic Review)。

IF 1 Q3 DENTISTRY, ORAL SURGERY & MEDICINE
eJournal of Oral Maxillofacial Research Pub Date : 2023-12-31 eCollection Date: 2023-10-01 DOI:10.5037/jomr.2023.14401
Rial Seluki, Moshe Seluki, Inga Vaitkeviciene, Egle Jagelaviciene
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引用次数: 0

摘要

研究目的本系统综述旨在评估目前关于药物相关性颌骨坏死保守治疗和手术治疗有效性的知识:通过MEDLINE (PubMed)、ScienceDirect和Cochrane图书馆检索,结合手工检索相关期刊,纳入了2017年1月至2023年2月期间发表的英文人类研究。纳入了评估药物相关性颌骨坏死(MRONJ)治疗策略的研究。采用乔安娜-布里格斯研究所(JBI)的偏倚风险工具对研究质量和偏倚风险进行评估:共筛选出 4227 篇文章,其中 9 项研究(7 项队列研究和 2 项随机对照试验)符合纳入标准,并被纳入最终数据综合。2项研究评估了保守方法治疗MRONJ的有效性,5项研究评估了手术方法的有效性,2项研究对这些方法进行了比较。随访时间从 6 个月到 60 个月不等。根据偏倚评估,纳入研究的平均JDI评分大于9分("偏倚风险低")。结论:手术治疗似乎优于保守治疗:结论:在治疗药物相关性颌骨骨坏死的不良阶段时,手术治疗似乎优于保守治疗,而对于无症状的早期颌骨骨坏死患者,保守治疗似乎能取得良好的疗效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparison of the Effectiveness of Conservative and Surgical Treatment of Medication-Related Osteonecrosis of the Jaw: a Systematic Review.

Objectives: The objective of this systematic review is to evaluate the current knowledge on the effectiveness of conservative and surgical treatment of medication-related osteonecrosis of the jaw.

Material and methods: MEDLINE (PubMed), ScienceDirect and Cochrane Library search in combination with hand-search of relevant journals was conducted including human studies published in English between January 2017 and February 2023. Studies assessing treatment strategies for medication-related osteonecrosis of the jaw (MRONJ) were included. Quality and risk-of-bias assessment were evaluated by Joanna Briggs Institute (JBI) Risk of Bias tool.

Results: A total of 4227 articles were screened from which 9 studies (7 cohort studies and 2 randomized controlled trials) met the inclusion criteria and were included in the final data synthesis. Two studies evaluate effectiveness of conservative approaches for treating MRONJ, 5 studies evaluate surgical approaches effectiveness, and 2 studies compare between those approaches. The follow-up period ranged from 6 months to 60 months. According to bias assessment, the mean JDI score of the included studies was > 9 ("low risk of bias"). The stage of the disease, the procedure performed on the patient and the results of the treatment were presented.

Conclusions: Surgical therapy seems to be superior to conservative therapy for the management of adverse stages medication-related osteonecrosis of the jaws, while conservative treatment appears to yield good outcomes at asymptomatic patients with early stages of the disease.

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