3 岁以下儿童的过敏症与母亲在怀孕期间摄入的 n-3 多不饱和脂肪酸或鱼类的水平有关:一项全国性出生队列研究--日本环境与儿童研究

IF 6.2 2区 医学 Q1 ALLERGY
Sayaka Tsuji , Yuichi Adachi , Akiko Tsuchida , Kei Hamazaki , Kenta Matsumura , Hidekuni Inadera
{"title":"3 岁以下儿童的过敏症与母亲在怀孕期间摄入的 n-3 多不饱和脂肪酸或鱼类的水平有关:一项全国性出生队列研究--日本环境与儿童研究","authors":"Sayaka Tsuji ,&nbsp;Yuichi Adachi ,&nbsp;Akiko Tsuchida ,&nbsp;Kei Hamazaki ,&nbsp;Kenta Matsumura ,&nbsp;Hidekuni Inadera","doi":"10.1016/j.alit.2023.12.004","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>N-3 polyunsaturated fatty acids (PUFAs) have anti-inflammatory properties and are expected to prevent the onset of allergies. However, epidemiological studies investigating the relationship between child allergies and maternal intake of n-3 PUFAs or fish have yielded inconsistent results.</p></div><div><h3>Methods</h3><p>Following exclusions from a dataset comprising 103,057 records from the Japan Environment and Children's Study, 72,105 participants were divided into five groups according to mothers' intake of n-3 PUFAs or fish during pregnancy to assess the risk of their children being diagnosed with allergy by 3 years old. Adjusted odds ratios (aORs) with 95% confidence intervals (CIs) for child allergies were calculated using multivariable logistic regression analyses with reference to the lowest intake group.</p></div><div><h3>Results</h3><p>Levels of maternal intake of n-3 PUFAs or fish showed inverted associations (i.e., reduced risk) with the incidence of physician-diagnosed allergic rhinoconjunctivitis or parent-reported symptoms of current rhinitis with eye symptoms at different time points and the cumulative incidence from birth to 3 years of age. Inverted associations were also found for current wheeze at 1-&lt;2 years of age and current eczema at 1-&lt;2 and 0-&lt;3 years of age. However, for food allergies, no significant associations were observed in the incidence in each group compared with the lowest intake group at any age.</p></div><div><h3>Conclusions</h3><p>The findings suggest that n-3 PUFA intake during pregnancy may reduce the risk of developing allergic diseases and symptoms in children. In addition, consumption of n-3 PUFAs or fish is very unlikely to increase the risk of allergy given that the results are from a country with high fish consumption. <em>Trial registration</em>: UMIN000030786 <span>https://rctportal.niph.go.jp/detail/um?trial_id=UMIN000030786</span><svg><path></path></svg>.</p></div>","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":null,"pages":null},"PeriodicalIF":6.2000,"publicationDate":"2024-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1323893023001399/pdfft?md5=a8dfb91dcfe73f986ecbddd82c6cd71d&pid=1-s2.0-S1323893023001399-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Association of allergies in children younger than 3 years with levels of maternal intake of n-3 polyunsaturated fatty acids or fish during pregnancy: A nationwide birth cohort study, the Japan Environment and Children's Study\",\"authors\":\"Sayaka Tsuji ,&nbsp;Yuichi Adachi ,&nbsp;Akiko Tsuchida ,&nbsp;Kei Hamazaki ,&nbsp;Kenta Matsumura ,&nbsp;Hidekuni Inadera\",\"doi\":\"10.1016/j.alit.2023.12.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>N-3 polyunsaturated fatty acids (PUFAs) have anti-inflammatory properties and are expected to prevent the onset of allergies. However, epidemiological studies investigating the relationship between child allergies and maternal intake of n-3 PUFAs or fish have yielded inconsistent results.</p></div><div><h3>Methods</h3><p>Following exclusions from a dataset comprising 103,057 records from the Japan Environment and Children's Study, 72,105 participants were divided into five groups according to mothers' intake of n-3 PUFAs or fish during pregnancy to assess the risk of their children being diagnosed with allergy by 3 years old. Adjusted odds ratios (aORs) with 95% confidence intervals (CIs) for child allergies were calculated using multivariable logistic regression analyses with reference to the lowest intake group.</p></div><div><h3>Results</h3><p>Levels of maternal intake of n-3 PUFAs or fish showed inverted associations (i.e., reduced risk) with the incidence of physician-diagnosed allergic rhinoconjunctivitis or parent-reported symptoms of current rhinitis with eye symptoms at different time points and the cumulative incidence from birth to 3 years of age. Inverted associations were also found for current wheeze at 1-&lt;2 years of age and current eczema at 1-&lt;2 and 0-&lt;3 years of age. However, for food allergies, no significant associations were observed in the incidence in each group compared with the lowest intake group at any age.</p></div><div><h3>Conclusions</h3><p>The findings suggest that n-3 PUFA intake during pregnancy may reduce the risk of developing allergic diseases and symptoms in children. In addition, consumption of n-3 PUFAs or fish is very unlikely to increase the risk of allergy given that the results are from a country with high fish consumption. <em>Trial registration</em>: UMIN000030786 <span>https://rctportal.niph.go.jp/detail/um?trial_id=UMIN000030786</span><svg><path></path></svg>.</p></div>\",\"PeriodicalId\":48861,\"journal\":{\"name\":\"Allergology International\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":6.2000,\"publicationDate\":\"2024-01-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1323893023001399/pdfft?md5=a8dfb91dcfe73f986ecbddd82c6cd71d&pid=1-s2.0-S1323893023001399-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Allergology International\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1323893023001399\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ALLERGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Allergology International","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1323893023001399","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ALLERGY","Score":null,"Total":0}
引用次数: 0

摘要

背景n-3多不饱和脂肪酸(PUFA)具有抗炎特性,有望预防过敏症的发生。方法从日本环境与儿童研究(Japan Environment and Children's Study)的 103,057 个记录数据集中排除后,根据母亲在怀孕期间摄入 n-3 PUFAs 或鱼类的情况将 72,105 名参与者分为五组,以评估其子女在 3 岁前被诊断出过敏的风险。结果母亲的 n-3 PUFAs 或鱼类摄入量水平与不同时间点医生诊断的过敏性鼻结膜炎发病率或家长报告的当前鼻炎症状和眼部症状以及从出生到 3 岁的累积发病率呈倒置关系(即风险降低)。1-<2 岁时的喘息和 1-<2 岁及 0-<3 岁时的湿疹也存在反向关联。结论 研究结果表明,孕期摄入 n-3 PUFA 可降低儿童患过敏性疾病和过敏症状的风险。此外,鉴于研究结果来自一个鱼类消费量较高的国家,因此食用 n-3 PUFA 或鱼类不太可能增加过敏风险。试验注册:umin000030786 https://rctportal.niph.go.jp/detail/um?trial_id=UMIN000030786。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association of allergies in children younger than 3 years with levels of maternal intake of n-3 polyunsaturated fatty acids or fish during pregnancy: A nationwide birth cohort study, the Japan Environment and Children's Study

Background

N-3 polyunsaturated fatty acids (PUFAs) have anti-inflammatory properties and are expected to prevent the onset of allergies. However, epidemiological studies investigating the relationship between child allergies and maternal intake of n-3 PUFAs or fish have yielded inconsistent results.

Methods

Following exclusions from a dataset comprising 103,057 records from the Japan Environment and Children's Study, 72,105 participants were divided into five groups according to mothers' intake of n-3 PUFAs or fish during pregnancy to assess the risk of their children being diagnosed with allergy by 3 years old. Adjusted odds ratios (aORs) with 95% confidence intervals (CIs) for child allergies were calculated using multivariable logistic regression analyses with reference to the lowest intake group.

Results

Levels of maternal intake of n-3 PUFAs or fish showed inverted associations (i.e., reduced risk) with the incidence of physician-diagnosed allergic rhinoconjunctivitis or parent-reported symptoms of current rhinitis with eye symptoms at different time points and the cumulative incidence from birth to 3 years of age. Inverted associations were also found for current wheeze at 1-<2 years of age and current eczema at 1-<2 and 0-<3 years of age. However, for food allergies, no significant associations were observed in the incidence in each group compared with the lowest intake group at any age.

Conclusions

The findings suggest that n-3 PUFA intake during pregnancy may reduce the risk of developing allergic diseases and symptoms in children. In addition, consumption of n-3 PUFAs or fish is very unlikely to increase the risk of allergy given that the results are from a country with high fish consumption. Trial registration: UMIN000030786 https://rctportal.niph.go.jp/detail/um?trial_id=UMIN000030786.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Allergology International
Allergology International ALLERGY-IMMUNOLOGY
CiteScore
12.60
自引率
5.90%
发文量
96
审稿时长
29 weeks
期刊介绍: Allergology International is the official journal of the Japanese Society of Allergology and publishes original papers dealing with the etiology, diagnosis and treatment of allergic and related diseases. Papers may include the study of methods of controlling allergic reactions, human and animal models of hypersensitivity and other aspects of basic and applied clinical allergy in its broadest sense. The Journal aims to encourage the international exchange of results and encourages authors from all countries to submit papers in the following three categories: Original Articles, Review Articles, and Letters to the Editor.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信