K2S2O8 介导的直接 C-H 功能化在水中合成喹喔啉-2(1H)-酮衍生物

IF 2.5 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

New Journal of Chemistry Pub Date : 2024-01-12 DOI:10.1039/D3NJ04784A

Hui Qin, Guo-Liang Wei, Xiao-Wei Zheng, Mei-Hua Bao, Yi-Wen Zhang and Ping Huang

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引用次数: 0

摘要

通过喹喔啉-2(1H)-酮与吲哚的直接 C(sp2)-C(sp3)键形成，开发了一种 K2S2O8 介导的方法。基于自由基偶联反应，提出了一种喹喔啉-2(1H)-酮与吲哚之间直接 C-H 功能化的高效可行策略。该方法提供了一个简明的方案，可在温和的条件下于水中以中等至良好的收率获得 3-(2-氧代吲哚-3-基)喹喔啉-2(1H)-酮。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

K2S2O8-mediated direct C–H functionalization to synthesize quinoxalin-2(1H)-one derivatives in water†

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K2S2O8-mediated direct C–H functionalization to synthesize quinoxalin-2(1H)-one derivatives in water†

A K₂S₂O₈-mediated direct C(sp²)–C(sp³) bond formation through quinoxalin-2(1H)-ones with oxindoles has been developed. An efficient and feasible strategy for direct C–H functionalization between quinoxalin-2(1H)-ones and oxindoles based on a radical coupling reaction is presented. This methodology provides a concise protocol to obtain 3-(2-oxoindolin-3-yl)quinoxalin-2(1H)-ones in water under mild conditions in moderate to good yields.