XiaoKun Zhao , Rui Ding , Kuo Sun , Wei Wang , Qiao Zhang , XiGao Cheng
{"title":"克氏分枝杆菌引起的股骨骨髓炎：病例报告","authors":"XiaoKun Zhao , Rui Ding , Kuo Sun , Wei Wang , Qiao Zhang , XiGao Cheng","doi":"10.1016/j.joscr.2023.12.005","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p><em>Mycobacterium chelonae</em> can cause infections of the lungs and soft tissues. However, osteomyelitis of the proximal femur caused by <em>M. chelonae</em> has not previously been reported. Here, we present such a case in an elderly patient.</p></div><div><h3>Case presentation</h3><p>A 69-year-old man presented with right hip pain for 1 month. The combination of MRI, laboratory examination, and next generation sequencing yielded the diagnosis of femoral osteomyelitis due to <em>M. chelonae</em>. Clarithromycin, moxifloxacin hydrochloride, linezolid, and amikacin were treated for 2 months. However, there was no significant improvement. Therefore, surgical debridement was taken, followed by combined treatment with amikacin, imipenem/cilastatin sodium, and clarithromycin 4 months. Re-examination a year later showed a significant reduction in the extent of disease.</p></div><div><h3>Conclusion</h3><p>Femoral osteomyelitis caused by <em>M. chelonae</em> is difficult to diagnose and treat. The key to successful treatment of this case is surgical debridement, as well as the combined antimicrobial agents.</p></div>","PeriodicalId":100743,"journal":{"name":"JOS Case Reports","volume":"3 2","pages":"Pages 92-96"},"PeriodicalIF":0.0000,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772964823000667/pdfft?md5=b330e69b97bbf34de29e772491688724&pid=1-s2.0-S2772964823000667-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Osteomyelitis of the femur caused by Mycobacterium chelonae: A case report\",\"authors\":\"XiaoKun Zhao , Rui Ding , Kuo Sun , Wei Wang , Qiao Zhang , XiGao Cheng\",\"doi\":\"10.1016/j.joscr.2023.12.005\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p><em>Mycobacterium chelonae</em> can cause infections of the lungs and soft tissues. However, osteomyelitis of the proximal femur caused by <em>M. chelonae</em> has not previously been reported. Here, we present such a case in an elderly patient.</p></div><div><h3>Case presentation</h3><p>A 69-year-old man presented with right hip pain for 1 month. The combination of MRI, laboratory examination, and next generation sequencing yielded the diagnosis of femoral osteomyelitis due to <em>M. chelonae</em>. Clarithromycin, moxifloxacin hydrochloride, linezolid, and amikacin were treated for 2 months. However, there was no significant improvement. Therefore, surgical debridement was taken, followed by combined treatment with amikacin, imipenem/cilastatin sodium, and clarithromycin 4 months. Re-examination a year later showed a significant reduction in the extent of disease.</p></div><div><h3>Conclusion</h3><p>Femoral osteomyelitis caused by <em>M. chelonae</em> is difficult to diagnose and treat. The key to successful treatment of this case is surgical debridement, as well as the combined antimicrobial agents.</p></div>\",\"PeriodicalId\":100743,\"journal\":{\"name\":\"JOS Case Reports\",\"volume\":\"3 2\",\"pages\":\"Pages 92-96\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-01-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2772964823000667/pdfft?md5=b330e69b97bbf34de29e772491688724&pid=1-s2.0-S2772964823000667-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"JOS Case Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2772964823000667\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"JOS Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2772964823000667","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Osteomyelitis of the femur caused by Mycobacterium chelonae: A case report
Background
Mycobacterium chelonae can cause infections of the lungs and soft tissues. However, osteomyelitis of the proximal femur caused by M. chelonae has not previously been reported. Here, we present such a case in an elderly patient.
Case presentation
A 69-year-old man presented with right hip pain for 1 month. The combination of MRI, laboratory examination, and next generation sequencing yielded the diagnosis of femoral osteomyelitis due to M. chelonae. Clarithromycin, moxifloxacin hydrochloride, linezolid, and amikacin were treated for 2 months. However, there was no significant improvement. Therefore, surgical debridement was taken, followed by combined treatment with amikacin, imipenem/cilastatin sodium, and clarithromycin 4 months. Re-examination a year later showed a significant reduction in the extent of disease.
Conclusion
Femoral osteomyelitis caused by M. chelonae is difficult to diagnose and treat. The key to successful treatment of this case is surgical debridement, as well as the combined antimicrobial agents.
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