Modeling animal genomics in mice: An authentic approach for the functional interrogation of evolutionarily and agriculturally critical variants

Mouse modeling could offer a powerful in vivo investigation tool for validating the functional role of candidate genes and genomic variants detected in animal and livestock species via multi-omic analyses. In this Commentary, the authors discuss the potential of transgenic and genome-edited mice as significant models for validating the outcomes of livestock genomic and multi-omic analyses.