猕猴杏仁核中阿尔茨海默病和相关痴呆症的病理学标志物

IF 3.4 3区医学 Q2 NEUROSCIENCES

Journal of Alzheimer's Disease Pub Date : 2024-01-09 DOI:10.3233/adr-230184

Jeremy L. Thomas, Benjamin I. Nilaver, Alejandro Lomniczi, Donald I. Brown, M. Appleman, S. Kohama, H. F. Urbanski

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引用次数: 0

摘要

猕猴在老年期会出现淀粉样蛋白-β（Aβ）斑块，但目前还不清楚它们如何广泛表达痴呆症的其他病理特征。在这里，我们使用免疫组化方法检测了磷酸化 tau（pTau）蛋白和 TAR DNA 结合蛋白 43 kDa（TDP-43）胞浆包涵体在年轻和年老雄性杏仁核中的表达情况，还检测了手术绝经的老年雌性杏仁核中的表达情况。只有一只 23 岁的雌性动物出现了 pTau 表达，没有任何动物出现 TDP-43 包涵体。究竟是什么遗传和/或环境因素保护猕猴不出现更严重的人类神经病理变化，这仍是一个有趣的未解之谜。

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Pathological Markers of Alzheimer’s Disease and Related Dementia in the Rhesus Macaque Amygdala

Rhesus macaques develop amyloid-β (Aβ) plaques during old age, but it is unclear how extensively they express other pathological hallmarks of dementia. Here we used immunohistochemistry to examine expression of phosphorylated tau (pTau) protein and cytoplasmic inclusions of TAR DNA binding protein 43 kDa (TDP-43) within the amygdala of young and old males, and also in old surgically-menopausal females that were maintained on regular or obesogenic diets. Only one animal, a 23-year-old female, showed pTau expression and none showed TDP-43 inclusions. What genetic and/or environmental factors protect macaques from expressing more severe human neuro-pathologies remains an interesting unresolved question.

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来源期刊

Journal of Alzheimer's Disease 医学-神经科学

CiteScore

6.40

自引率

7.50%

发文量

1327

审稿时长

2 months

期刊介绍： The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.