交替 RNA 剪接产生不同类型癌症的共享克隆新抗原

IF 67.7 1区医学 Q1 IMMUNOLOGY

Nature Reviews Immunology Pub Date : 2024-01-12 DOI:10.1038/s41577-023-00986-3

Matthew Brown, Nicolas Vabret

引用次数: 0

摘要

Kwok 等人的一篇预发表论文描述了常见的新结合源抗原的鉴定，这些抗原可作为 "现成 "疫苗或采用细胞疗法的靶点，用于治疗各种类型的癌症患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Alternative RNA splicing generates shared clonal neoantigens across different types of cancer

A preprint by Kwok et al. describes the identification of common neojunction-derived antigens that could serve as targets for ‘off the shelf’ vaccines or adoptive cell therapies for patients with various types of cancer.

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来源期刊

Nature Reviews Immunology 医学-免疫学

CiteScore

93.40

自引率

0.40%

发文量

131

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Immunology is a journal that provides comprehensive coverage of all areas of immunology, including fundamental mechanisms and applied aspects. It has two international standard serial numbers (ISSN): 1474-1733 for print and 1474-1741 for online. In addition to review articles, the journal also features recent developments and new primary papers in the field, as well as reflections on influential people, papers, and events in the development of immunology. The subjects covered by Nature Reviews Immunology include allergy and asthma, autoimmunity, antigen processing and presentation, apoptosis and cell death, chemokines and chemokine receptors, cytokines and cytokine receptors, development and function of cells of the immune system, haematopoiesis, infection and immunity, immunotherapy, innate immunity, mucosal immunology and the microbiota, regulation of the immune response, signalling in the immune system, transplantation, tumour immunology and immunotherapy, and vaccine development.