造血干细胞移植后预防巨细胞病毒感染的勒替莫韦的有效性和安全性。

IF 1.5 Q3 HEMATOLOGY
血液科学(英文) Pub Date : 2024-01-10 eCollection Date: 2024-01-01 DOI:10.1097/BS9.0000000000000178
Wen-Wen Li, Yong-Mei Zhang, Meng-Zhu Shen, Xiao-Dong Mo
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引用次数: 0

摘要

来替莫韦是巨细胞病毒(CMV)终结酶复合物的特异性抑制剂。多项研究表明,来替莫韦能有效预防异基因造血干细胞移植(allo-HSCT)后的CMV激活。我们的目的是通过系统综述和荟萃分析来确定allo-HSCT后预防CMV感染的效果和安全性。按照《系统综述和荟萃分析首选报告项目》声明进行了文献检索。检索了 PubMed 和 Embase 数据库。共纳入 28 项研究。造血干细胞移植后 14 周时,CMV 激活的发生率为 0.10(95% 置信区间 [CI],0.06-0.18),成人为 0.10(95% 置信区间 [CI],0.04-0.21),儿童为 0%(纳入 2 项研究,均为 0%)。此外,在回顾性研究和前瞻性研究中,allo-HSCT 后 14 周 CMV 激活的发生率分别为 0.11(95% CI,0.06-0.21)和 0.07(仅纳入 1 项研究)。造血干细胞移植后100天和200天的CMV激活发生率分别为0.23(95% CI,0.16-0.33)和0.49(95% CI,0.32-0.67)。造血干细胞移植后14周和6个月时CMV疾病的发生率分别为0.01(95% CI,0.01-0.02)和0.03(95% CI,0.01-0.09)。因此,我们的系统综述和荟萃分析表明,在allo-HSCT后预防CMV激活是安全有效的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Efficacy and safety of letermovir prophylaxis for cytomegalovirus infection after hematopoietic stem cell transplantation.

Letermovir is a specific inhibitor of cytomegalovirus (CMV) terminase complex. Several studies have reported that letermovir can effectively prevent CMV activation after allogeneic hematopoietic stem cell transplantation (allo-HSCT). We aimed to identify the efficacy and safety of letermovir prophylaxis for CMV infection after allo-HSCT with a systemic review and meta-analysis. A literature search was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-analyses statement. PubMed and Embase databases were searched. A total of 28 studies were included. The incidence of CMV activation at 14 weeks after HSCT was 0.10 (95% confidence interval [CI], 0.06-0.18), which was 0.10 (95% CI, 0.04-0.21) and 0% in adult and children (2 studies were included and both of them were 0%). In addition, the incidence of CMV activation at 14 weeks after allo-HSCT was 0.11 (95% CI, 0.06-0.21) and 0.07 (only 1 study included), respectively, in retrospective and prospective studies. The incidence of CMV activation at 100 and 200 days after HSCT was 0.23 (95% CI, 0.16-0.33) and 0.49 (95% CI, 0.32-0.67), respectively. The incidence of CMV disease at 14 weeks and at 6 months after HSCT was 0.01 (95% CI, 0.01-0.02) and 0.03 (95% CI, 0.01-0.09), respectively. Thus, our systemic review and meta-analysis suggested that letermovir prophylaxis was safe and effective for CMV activation after allo-HSCT.

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来源期刊
CiteScore
1.70
自引率
0.00%
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审稿时长
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