Ngoc The Nguyen, Van Toan Nguyen, Thanh Tam Vu, Tuong Vi Le Nguyen, Trang Thuy Thi Nguyen, Phuong Duy Huynh, Binh An Pham, Ngoc Quyen Tran, Dinh Trung Nguyen, Phuong Le Thi
{"title":"褐藻糖胶-褐藻糖胶 F127 纳米凝胶高效、可控地联合递送紫杉醇和姜黄素，协同治疗乳腺癌","authors":"Ngoc The Nguyen, Van Toan Nguyen, Thanh Tam Vu, Tuong Vi Le Nguyen, Trang Thuy Thi Nguyen, Phuong Duy Huynh, Binh An Pham, Ngoc Quyen Tran, Dinh Trung Nguyen, Phuong Le Thi","doi":"10.1007/s13233-023-00240-8","DOIUrl":null,"url":null,"abstract":"<div><p>The co-delivery of paclitaxel (PTX) and curcumin (Cur) has proven to be an effective method for breast cancer treatment. However, the poor solubility of both PTX and Cur limits their bioavailability, resulting in insufficient anticancer effects. Herein, we developed a novel nanogel based on fucoidan to facilitate the co-encapsulation of PTX and Cur and improve their therapeutic effectiveness. The thermosensitive copolymer, fucoidan-pluronic F127 (Fud-F127), was synthesized and characterized by various techniques, including proton nuclear magnetic resonance (<sup>1</sup>H-NMR), transmission electron microscopy (TEM), dynamic light scattering (DLS), and critical micelle concentration (CMC). Cur and PTX were easily loaded into the Fud-F127 nanogel (Fud-F127@Cur@PTX), with high drug loading capacity of 84.4% for Cur and 86.83% for PTX. The PTX and Cur were sustainedly released followed a Fickian diffusion mechanism and triggered at acidic pH 5.5. In vitro assessments demonstrated that Fud-F127@Cur@PTX exhibited lower cytotoxicity towards breast cancer cells (MCF-7) than Fud-F127@PTX and free PTX at the same dose, highlighting the potential of Cur in mitigating the acute toxicity of PTX. These results suggest the potential of Fud-F127 as an effective nanocarrier for the co-delivery of PTX and Cur, which aims to minimize the adverse effects associated with breast cancer treatment.</p><h3>Graphical abstract</h3><p>\nFud-F127 nanogel system encapsulating Cur and PTX for enhanced delivery</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"32 5","pages":"427 - 442"},"PeriodicalIF":2.8000,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Efficient and controllable co-delivery of paclitaxel and curcumin from fucoidan-pluronic F127 nanogel for synergistic breast cancer treatment\",\"authors\":\"Ngoc The Nguyen, Van Toan Nguyen, Thanh Tam Vu, Tuong Vi Le Nguyen, Trang Thuy Thi Nguyen, Phuong Duy Huynh, Binh An Pham, Ngoc Quyen Tran, Dinh Trung Nguyen, Phuong Le Thi\",\"doi\":\"10.1007/s13233-023-00240-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The co-delivery of paclitaxel (PTX) and curcumin (Cur) has proven to be an effective method for breast cancer treatment. However, the poor solubility of both PTX and Cur limits their bioavailability, resulting in insufficient anticancer effects. Herein, we developed a novel nanogel based on fucoidan to facilitate the co-encapsulation of PTX and Cur and improve their therapeutic effectiveness. The thermosensitive copolymer, fucoidan-pluronic F127 (Fud-F127), was synthesized and characterized by various techniques, including proton nuclear magnetic resonance (<sup>1</sup>H-NMR), transmission electron microscopy (TEM), dynamic light scattering (DLS), and critical micelle concentration (CMC). Cur and PTX were easily loaded into the Fud-F127 nanogel (Fud-F127@Cur@PTX), with high drug loading capacity of 84.4% for Cur and 86.83% for PTX. The PTX and Cur were sustainedly released followed a Fickian diffusion mechanism and triggered at acidic pH 5.5. In vitro assessments demonstrated that Fud-F127@Cur@PTX exhibited lower cytotoxicity towards breast cancer cells (MCF-7) than Fud-F127@PTX and free PTX at the same dose, highlighting the potential of Cur in mitigating the acute toxicity of PTX. These results suggest the potential of Fud-F127 as an effective nanocarrier for the co-delivery of PTX and Cur, which aims to minimize the adverse effects associated with breast cancer treatment.</p><h3>Graphical abstract</h3><p>\\nFud-F127 nanogel system encapsulating Cur and PTX for enhanced delivery</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":688,\"journal\":{\"name\":\"Macromolecular Research\",\"volume\":\"32 5\",\"pages\":\"427 - 442\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2024-01-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Macromolecular Research\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s13233-023-00240-8\",\"RegionNum\":4,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"POLYMER SCIENCE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Macromolecular Research","FirstCategoryId":"5","ListUrlMain":"https://link.springer.com/article/10.1007/s13233-023-00240-8","RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
引用次数: 0
摘要
事实证明，紫杉醇（PTX）和姜黄素（Cur）联合给药是治疗乳腺癌的有效方法。然而，紫杉醇和姜黄素的溶解度较低，限制了它们的生物利用度，导致抗癌效果不佳。在此，我们开发了一种基于褐藻糖胶的新型纳米凝胶，以促进 PTX 和 Cur 的共包囊，提高它们的治疗效果。我们合成了热敏共聚物褐藻糖胶-葡聚糖 F127（Fud-F127），并通过质子核磁共振（1H-NMR）、透射电子显微镜（TEM）、动态光散射（DLS）和临界胶束浓度（CMC）等多种技术对其进行了表征。Fud-F127纳米凝胶（Fud-F127@Cur@PTX）很容易负载Cur和PTX，Cur和PTX的载药量分别为84.4%和86.83%。PTX 和 Cur 的持续释放遵循 Fickian 扩散机制，并在 pH 值为 5.5 的酸性条件下触发。体外评估表明，在相同剂量下，Fud-F127@Cur@PTX 对乳腺癌细胞（MCF-7）的细胞毒性低于 Fud-F127@PTX 和游离 PTX，这凸显了 Cur 在减轻 PTX 急性毒性方面的潜力。这些结果表明，Fud-F127有可能成为一种有效的纳米载体，用于联合递送PTX和Cur，从而最大限度地减少与乳腺癌治疗相关的不良反应。 图文摘要Fud-F127纳米凝胶系统包裹Cur和PTX以增强递送效果
Efficient and controllable co-delivery of paclitaxel and curcumin from fucoidan-pluronic F127 nanogel for synergistic breast cancer treatment
The co-delivery of paclitaxel (PTX) and curcumin (Cur) has proven to be an effective method for breast cancer treatment. However, the poor solubility of both PTX and Cur limits their bioavailability, resulting in insufficient anticancer effects. Herein, we developed a novel nanogel based on fucoidan to facilitate the co-encapsulation of PTX and Cur and improve their therapeutic effectiveness. The thermosensitive copolymer, fucoidan-pluronic F127 (Fud-F127), was synthesized and characterized by various techniques, including proton nuclear magnetic resonance (1H-NMR), transmission electron microscopy (TEM), dynamic light scattering (DLS), and critical micelle concentration (CMC). Cur and PTX were easily loaded into the Fud-F127 nanogel (Fud-F127@Cur@PTX), with high drug loading capacity of 84.4% for Cur and 86.83% for PTX. The PTX and Cur were sustainedly released followed a Fickian diffusion mechanism and triggered at acidic pH 5.5. In vitro assessments demonstrated that Fud-F127@Cur@PTX exhibited lower cytotoxicity towards breast cancer cells (MCF-7) than Fud-F127@PTX and free PTX at the same dose, highlighting the potential of Cur in mitigating the acute toxicity of PTX. These results suggest the potential of Fud-F127 as an effective nanocarrier for the co-delivery of PTX and Cur, which aims to minimize the adverse effects associated with breast cancer treatment.
Graphical abstract
Fud-F127 nanogel system encapsulating Cur and PTX for enhanced delivery
期刊介绍：
Original research on all aspects of polymer science, engineering and technology, including nanotechnology
Presents original research articles on all aspects of polymer science, engineering and technology
Coverage extends to such topics as nanotechnology, biotechnology and information technology
The English-language journal of the Polymer Society of Korea
Macromolecular Research is a scientific journal published monthly by the Polymer Society of Korea. Macromolecular Research publishes original researches on all aspects of polymer science, engineering, and technology as well as new emerging technologies using polymeric materials including nanotechnology, biotechnology, and information technology in forms of Articles, Communications, Notes, Reviews, and Feature articles.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
