COVID-19 患者合并感染的特征。

The Canadian journal of hospital pharmacy Pub Date : 2024-01-10 eCollection Date: 2024-01-01 DOI:10.4212/cjhp.3398
Alexander Pai, Zahra Kanji, James Joshua Douglas
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引用次数: 0

摘要

背景:人们对 COVID-19 患者的合并感染知之甚少:人们对COVID-19患者的合并感染知之甚少,通常都是根据经验使用抗生素:目的:确定 COVID-19 患者早期和晚期合并感染的发生率和特征,并描述抗感染药物(尤其是抗生素)的使用情况:这项回顾性病历审查涉及 2020 年 1 月 1 日至 6 月 30 日期间入住狮门医院(不列颠哥伦比亚省温哥华市)的 COVID-19 患者。数据提取自电子病历,并采用描述性统计方法对数据进行分析:在研究期间入院的 48 名患者中,有 10 人(21%)被确定患有合并感染:3人(6%)为早期合并感染,7人(15%)为晚期合并感染。有 32 名(67%)患者早期使用了经验性抗生素;在这 32 名患者中,有 29 名(91%)被认为治疗不当。合并感染的患者住院时间更长,并发症更多:尽管早期合并感染率较低,但大多数患者都开始使用经验性抗生素。大多数晚期合并感染发生在需要机械通气的重症监护室患者身上。合并感染的患者比未合并感染的患者预后更差。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Characterization of Coinfections in Patients with COVID-19.

Background: Little is known about coinfections in patients with COVID-19, with antibiotics often initiated empirically.

Objectives: To determine the rates and characteristics of early and late coinfections in COVID-19 patients and to characterize the use of anti-infective agents, especially antibiotics.

Methods: This retrospective chart review involved patients with COVID-19 who were admitted to Lions Gate Hospital (Vancouver, British Columbia) between January 1 and June 30, 2020. Data were extracted from electronic medical records, and descriptive statistics were used to analyze the data.

Results: Of the 48 patients admitted during the study period, 10 (21%) were determined to have coinfections: 3 (6%) had early coinfections and 7 (15%) had late coinfections. Early empiric use of antibiotics was observed in 32 (67%) patients; for 29 (91%) of these 32 patients, the therapy was deemed inappropriate. Patients with coinfections had longer hospital stays and more complications.

Conclusions: Despite low rates of early coinfection, empiric antibiotics were started for a majority of the patients. Most late coinfections occurred in patients in the intensive care unit who required mechanical ventilation. Patients with coinfections had poorer outcomes than those without coinfections.

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