角膜移植的质量保证:捐献角膜的评估和监督。

IF 5.1 2区 医学 Q1 OPHTHALMOLOGY
Vito Romano , Maria Laura Passaro , Alessandro Ruzza , Mohit Parekh , Matteo Airaldi , Hannah J. Levis , Stefano Ferrari , Ciro Costagliola , Francesco Semeraro , Diego Ponzin
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引用次数: 0

摘要

角膜是最常移植的人体组织,角膜移植是全世界最成功的异体移植手术。为了获得良好的手术效果和视觉康复效果,并确保受体的安全,在整个过程中必须对捐献者和捐献组织进行准确筛查。这可以降低传染病和环境污染等传染给受体的风险,并确保组织具有较高的光学和功能质量。整个过程可分为三个阶段:(1) 取材小组在组织采集前对捐献者进行评估和选择;(2) 取材后眼库技术人员在储存阶段对组织进行分析;(3) 移植前外科医生在手术室对组织进行质量检查。虽然多年来流程的改进大大提高了角膜移植的安全性、质量和结果,但各中心在流程的某些阶段仍然缺乏标准化,这可能会影响移植角膜的质量和数量。在此,我们将详细介绍角膜取回小组、眼库操作员和眼科医生的捐献者筛选过程,并研究与每个阶段相关的局限性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Quality assurance in corneal transplants: Donor cornea assessment and oversight

The cornea is the most frequently transplanted human tissue, and corneal transplantation represents the most successful allogeneic transplant worldwide. In order to obtain good surgical outcome and visual rehabilitation and to ensure the safety of the recipient, accurate screening of donors and donor tissues is necessary throughout the process. This mitigates the risks of transmission to the recipient, including infectious diseases and environmental contaminants, and ensures high optical and functional quality of the tissues. The process can be divided into 3 stages: (1) donor evaluation and selection before tissue harvest performed by the retrieval team, (2) tissue analysis during the storage phase conducted by the eye bank technicians after the retrieval, and, (3) tissue quality checks undertaken by the surgeons in the operating room before transplantation. Although process improvements over the years have greatly enhanced safety, quality, and outcome of the corneal transplants, a lack of standardization between centers during certain phases of the process still remains, and may impact on the quality and number of transplanted corneas. Here we detail the donor screening process for the retrieval teams, eye bank operators. and ophthalmic surgeons and examine the limitations associated with each of these stages.

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来源期刊
Survey of ophthalmology
Survey of ophthalmology 医学-眼科学
CiteScore
10.30
自引率
2.00%
发文量
138
审稿时长
14.8 weeks
期刊介绍: Survey of Ophthalmology is a clinically oriented review journal designed to keep ophthalmologists up to date. Comprehensive major review articles, written by experts and stringently refereed, integrate the literature on subjects selected for their clinical importance. Survey also includes feature articles, section reviews, book reviews, and abstracts.
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