利用肿瘤外泌体:扩大前列腺癌临床诊断、预后和治疗效果的可行方法。

IF 5 3区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
BioFactors Pub Date : 2024-01-11 DOI:10.1002/biof.2036
Mohammad-Bagher Pirouzpanah, Soraya Babaie, Samira Pourzeinali, Hamed Valizadeh, Samira Malekeh, Fikrettin Şahin, Azizeh Farshbaf-Khalili
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引用次数: 0

摘要

前列腺癌是导致全球男性死亡的第二大原因。尽管对局部前列腺癌的早期诊断和治疗有所改善,但每年仍有大多数患有转移性疾病的男性死于前列腺癌。因此,确定前列腺癌进展的细胞-分子机制对于克服受控增殖、侵袭和转移至关重要。外泌体是一种小型细胞外囊泡,可介导大多数细胞的相互作用,其中含有膜蛋白、细胞膜和核蛋白、细胞外基质蛋白、脂质、代谢物和核酸。外泌体在旁分泌途径中发挥着重要作用,可能通过多种机制影响前列腺癌的进展。在本综述中,我们概述并讨论了在了解外泌体在前列腺癌微环境中的作用方面取得的最新进展,如外泌体参与前列腺癌的发生、发展、血管生成、上皮-间质转化、转移和耐药性。我们还介绍了有关外泌体作为生物标记物的功能、前列腺癌的直接治疗靶点、将外泌体作为天然载体和基于外泌体的免疫疗法所面临的挑战和优势的最新发现。这些发现为拓展潜在的临床方法提供了一条充满希望的途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Harnessing tumor-derived exosomes: A promising approach for the expansion of clinical diagnosis, prognosis, and therapeutic outcome of prostate cancer

Harnessing tumor-derived exosomes: A promising approach for the expansion of clinical diagnosis, prognosis, and therapeutic outcome of prostate cancer

Prostate cancer is the second leading cause of men's death worldwide. Although early diagnosis and therapy for localized prostate cancer have improved, the majority of men with metastatic disease die from prostate cancer annually. Therefore, identification of the cellular-molecular mechanisms underlying the progression of prostate cancer is essential for overcoming controlled proliferation, invasion, and metastasis. Exosomes are small extracellular vesicles that mediate most cells' interactions and contain membrane proteins, cytosolic and nuclear proteins, extracellular matrix proteins, lipids, metabolites, and nucleic acids. Exosomes play an essential role in paracrine pathways, potentially influencing Prostate cancer progression through a wide variety of mechanisms. In the present review, we outline and discuss recent progress in our understanding of the role of exosomes in the Prostate cancer microenvironment, like their involvement in prostate cancer occurrence, progression, angiogenesis, epithelial–mesenchymal transition, metastasis, and drug resistance. We also present the latest findings regarding the function of exosomes as biomarkers, direct therapeutic targets in prostate cancer, and the challenges and advantages associated with using exosomes as natural carriers and in exosome-based immunotherapy. These findings are a promising avenue for the expansion of potential clinical approaches.

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来源期刊
BioFactors
BioFactors 生物-内分泌学与代谢
CiteScore
11.50
自引率
3.30%
发文量
96
审稿时长
6-12 weeks
期刊介绍: BioFactors, a journal of the International Union of Biochemistry and Molecular Biology, is devoted to the rapid publication of highly significant original research articles and reviews in experimental biology in health and disease. The word “biofactors” refers to the many compounds that regulate biological functions. Biological factors comprise many molecules produced or modified by living organisms, and present in many essential systems like the blood, the nervous or immunological systems. A non-exhaustive list of biological factors includes neurotransmitters, cytokines, chemokines, hormones, coagulation factors, transcription factors, signaling molecules, receptor ligands and many more. In the group of biofactors we can accommodate several classical molecules not synthetized in the body such as vitamins, micronutrients or essential trace elements. In keeping with this unified view of biochemistry, BioFactors publishes research dealing with the identification of new substances and the elucidation of their functions at the biophysical, biochemical, cellular and human level as well as studies revealing novel functions of already known biofactors. The journal encourages the submission of studies that use biochemistry, biophysics, cell and molecular biology and/or cell signaling approaches.
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