使用血凝酶和氨甲环酸减少转子间骨折 PFNA 固定术围手术期失血的有效性和安全性。

IF 0.5 4区 医学 Q4 ORTHOPEDICS
L Wang, C Wang, D Zhang, W Wang, F Wang
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引用次数: 0

摘要

本研究评估了血凝酶和氨甲环酸(TXA)在股骨近端钉抗旋转(PFNA)修复术围手术期减少围手术期失血的疗效。99名接受股骨转子间骨折PFNA固定术的患者被随机分配到血凝酶组、氨甲环酸组和对照组(每组33人)。血凝酶组分别在术前注射1 KU血凝酶,术后局部喷雾;TXA组分别在术前注射0.5克TXA,术后局部喷雾;对照组分别在术前注射100毫升生理盐水,术后局部喷雾。与对照组相比,血凝酶组和 TXA 组在术前血红蛋白(HB)和术后第 1 天和第 3 天血细胞比容(HCT)水平、术中出血量、术后 24 小时引流量、围手术期总出血量、输血率和术后住院时间方面均有显著差异。此外,与对照组相比,血凝酶组和 TXA 组在术后第 3 天 HB 和 HCT 水平以及术后住院时间方面存在显著差异。总之,在接受 PFNA 手术的转子间骨折患者中,术前全身和术后局部联合使用血凝酶和 TXA 喷雾剂可显著减少围术期失血。据观察,血凝酶的效果优于 TXA。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effectiveness and safeties of hemocoagulase and tranexamic acid to reduce perioperative blood loss in intertrochanteric fracture PFNA fixation.

This study evaluated the efficacy of hemocoagulase and tranexamic acid (TXA) in minimizing perioperative blood loss in perioperative period of proximal femoral nail antirotation (PFNA) repair. 99 patients having intertrochanteric fracture PFNA fixation were randomly assigned to the hemocoagulase, TXA, and control groups (n=33 per group). In the hemocoagulase group, 1 KU of hemocoagulase was injected preoperatively and postoperatively local sprayed, respectively; in the TXA group, 0.5g TXA was injected preoperatively and postoperatively local sprayed, respectively; and in the control group, 100 mL of physiological saline was injected before surgery and was used by postoperative local spraying, respectively. The hemocoagulase and TXA groups exhibited significant differences in preoperative hemoglobin (HB) and hematocrit (HCT) levels on postoperative days 1 and 3, intraoperative bleeding, 24-hour postoperative drainage, total perioperative bleeding, transfusion rate, and postoperative hospitalization duration compared to the control group. Furthermore, the hemocoagulase and TXA groups showed significant differences in postoperative day 3 HB and HCT levels and postoperative hospitalization duration compared to each other. In conclusions, the combined use of systemic preoperative and local postoperative hemocoagulase and TXA spraying is found to significantly decrease perioperative blood loss in intertrochanteric fracture patients undergoing PFNA. Hemocoagulase is observed to have a superior effect compared to TXA.

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来源期刊
Acta orthopaedica Belgica
Acta orthopaedica Belgica 医学-整形外科
CiteScore
0.70
自引率
0.00%
发文量
58
审稿时长
4-8 weeks
期刊介绍: Information not localized
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