作为药物化学培训的全合成

IF 4 3区医学 Q2 CHEMISTRY, MEDICINAL

ACS Medicinal Chemistry Letters Pub Date : 2024-01-10 DOI:10.1021/acsmedchemlett.3c00556

Lewis D. Pennington*,

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引用次数: 0

摘要

关于在当今制药和生物技术行业从事现代药物化学的最佳学术培训类型，一直存在争论。本 "视点 "将论证全合成作为药物化学培训的持续价值，或许这种价值还在不断增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Total Synthesis as Training for Medicinal Chemistry

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Total Synthesis as Training for Medicinal Chemistry

There is an ongoing debate about the best types of training in academia for practicing modern medicinal chemistry in the pharmaceutical and biotechnology industries of today. A case is made in this Viewpoint for the ongoing, and perhaps increasing, value of total synthesis as training for medicinal chemistry.

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来源期刊

ACS Medicinal Chemistry Letters CHEMISTRY, MEDICINAL-

CiteScore

7.30

自引率

2.40%

发文量

328

审稿时长

1 months

期刊介绍： ACS Medicinal Chemistry Letters is interested in receiving manuscripts that discuss various aspects of medicinal chemistry. The journal will publish studies that pertain to a broad range of subject matter, including compound design and optimization, biological evaluation, drug delivery, imaging agents, and pharmacology of both small and large bioactive molecules. Specific areas include but are not limited to: Identification, synthesis, and optimization of lead biologically active molecules and drugs (small molecules and biologics) Biological characterization of new molecular entities in the context of drug discovery Computational, cheminformatics, and structural studies for the identification or SAR analysis of bioactive molecules, ligands and their targets, etc. Novel and improved methodologies, including radiation biochemistry, with broad application to medicinal chemistry Discovery technologies for biologically active molecules from both synthetic and natural (plant and other) sources Pharmacokinetic/pharmacodynamic studies that address mechanisms underlying drug disposition and response Pharmacogenetic and pharmacogenomic studies used to enhance drug design and the translation of medicinal chemistry into the clinic Mechanistic drug metabolism and regulation of metabolic enzyme gene expression Chemistry patents relevant to the medicinal chemistry field.