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引用次数: 0
摘要
以往的干预研究表明，黑巧克力对心血管系统有一定的益处，但黑巧克力的摄入量是否与心血管疾病（CVDs）的风险有关尚未确定。为了研究黑巧克力摄入量与心血管疾病风险之间的因果关系，我们开展了一项孟德尔随机化（MR）研究。我们从公开的全基因组关联研究中获得了黑巧克力摄入量和心血管疾病的汇总数据。在这项 MR 研究中，主要方法是使用反方差加权（IVW）固定效应模型，并通过敏感性分析评估结果的稳健性。我们发现，黑巧克力的摄入量与本质性高血压（EH）风险的降低显著相关（OR = 0.73; 95% CI 0.60-0.88; p = 1.06 × 10-3），与静脉血栓栓塞风险的降低也有提示性关联（OR = 0.69; 95% CI 0.50-0.96; p = 2.81 × 10-2）。然而，黑巧克力摄入量与其他十种心血管疾病之间没有关联。我们的研究为黑巧克力摄入量与降低 EH 风险之间的因果关系提供了证据，这对在人群中预防 EH 具有重要意义。
Dark chocolate intake and cardiovascular diseases: a Mendelian randomization study
Previous intervention studies have shown some benefits of dark chocolate for the cardiovascular system, but it has not been established whether dark chocolate intake is associated with the risk of cardiovascular diseases (CVDs). To investigate the causality between dark chocolate intake and the risk of CVDs, a Mendelian randomization (MR) study was conducted. We obtained summary-level data on dark chocolate intake and CVDs from publicly available genome-wide association studies. In this MR study, the main approach was to use a fixed-effect model with inverse variance weighted (IVW) and evaluate the robustness of the results via sensitivity analysis. We found that dark chocolate intake was significantly associated with the reduction of the risk of essential hypertension (EH) (OR = 0.73; 95% CI 0.60–0.88; p = 1.06 × 10−3), as well as with the suggestive association to the reduced risk of venous thromboembolism (OR = 0.69; 95% CI 0.50–0.96; p = 2.81 × 10−2). However, no association was found between dark chocolate intake and the other ten CVDs. Our study provides evidence for a causality between dark chocolate intake and a reduced risk of EH, which has important implications for the prevention of EH in the population.
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