揭示 T 细胞在神经退行性疾病中的关键作用，有望开发出新的靶向疗法。

IF 1.8 4区医学 Q4 NEUROSCIENCES

Translational Neuroscience Pub Date : 2023-12-31 eCollection Date: 2023-01-01 DOI:10.1515/tnsci-2022-0329

Haofuzi Zhang, Xiaofan Jiang

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引用次数: 0

摘要

华盛顿大学医学院的戴维-霍尔茨曼（David M. Holtzman）及其团队在神经退行性疾病的研究中取得了突破性进展。他们发现，在活化的小胶质细胞的煽动下，T 细胞渗入大脑是导致牛磺酸病进展的关键因素。这一突破性研究成果于2023年3月8日发表在《自然》杂志上。这项研究勾勒出了一个与tauopathy和神经退行性病变有关的关键免疫枢纽；一个涉及活化小胶质细胞和T细胞反应的复杂相互作用。这一发现有可能成为开发阿尔茨海默病和原发性神经变性治疗干预措施的目标。

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Revealing key role of T cells in neurodegenerative diseases, with potential to develop new targeted therapies.

David M. Holtzman and his team at the University of Washington School of Medicine have made breakthroughs in their research on neurodegenerative diseases. They discovered that the infiltration of T cells into the brain, instigated by activated microglia, is a critical factor in the progression of tauopathy. The groundbreaking findings were published in Nature on March 8, 2023. This research delineates a pivotal immune hub linked to tauopathy and neurodegeneration; a complex interplay involving activated microglia and T cell responses. This discovery could potentially become a target for developing therapeutic interventions for Alzheimer's disease and primary neurodegeneration.

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来源期刊

Translational Neuroscience NEUROSCIENCES-

CiteScore

3.00

自引率

4.80%

发文量

审稿时长

>12 weeks

期刊介绍： Translational Neuroscience provides a closer interaction between basic and clinical neuroscientists to expand understanding of brain structure, function and disease, and translate this knowledge into clinical applications and novel therapies of nervous system disorders.