离子液体与脂质双分子层:最新进展综述。

IF 4.9 Q1 BIOPHYSICS
Biophysical reviews Pub Date : 2024-01-02 eCollection Date: 2023-12-01 DOI:10.1007/s12551-023-01173-3
Antonio Benedetto
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引用次数: 0

摘要

在过去的 25 年中,被称为室温离子液体(ILs)的一大类复杂有机盐因其潜在的应用而受到越来越多的关注。离子液体由一个有机阳离子和一个有机或无机阴离子组成,具有一些引人入胜的特性,如低蒸气压和室温下呈液态。一些生物研究表明,它们具有中度到高度(细胞)毒性。然而,毒性也是亲和力的代名词,这推动了一系列生物物理和化学物理研究,旨在利用 ILs 进行生物纳米医学、药物输送、药理学和生物纳米技术研究。其中几项研究的重点是 ILs 与脂膜之间的相互作用,旨在确定其相互作用背后的微观机制。这也是本综述的重点。这些研究是在各种不同的脂质双分子层系统(从单脂到五脂系统)以及细胞提取膜上进行的。这些研究在不同的化学物理条件下进行,并采用了多种不同的方法,包括原子力显微镜、中子和 X 射线散射、动态光散射、差示扫描量热仪、表面石英微天平、核磁共振、共焦荧光显微镜和分子动力学模拟。本 "2023 米歇尔-奥格奖 "综述旨在为读者提供 "IL 与脂质双层膜(又称生物膜)"这一迷人研究领域的最新概况,目的是进一步推动该领域的发展,扩大其跨学科优势,在药理学、药物输送、生物医学和生物纳米技术领域实现具有重大影响的新想法/应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ionic liquids meet lipid bilayers: a state-of-the-art review.

In the past 25 years, a vast family of complex organic salts known as room-temperature ionic liquids (ILs) has received increasing attention due to their potential applications. ILs are composed by an organic cation and either an organic or inorganic anion, and possess several intriguing properties such as low vapor pressure and being liquid around room temperature. Several biological studies flagged their moderate-to-high (cyto)-toxicity. Toxicity is, however, also a synonym of affinity, and this boosted a series of biophysical and chemical-physical investigations aimed at exploiting ILs in bio-nanomedicine, drug-delivery, pharmacology, and bio-nanotechnology. Several of these investigations focused on the interaction between ILs and lipid membranes, aimed at determining the microscopic mechanisms behind their interaction. This is the focus of this review work. These studies have been carried out on a variety of different lipid bilayer systems ranging from 1-lipid to 5-lipids systems, and also on cell-extracted membranes. They have been carried out at different chemical-physical conditions and by the use of a number of different approaches, including atomic force microscopy, neutron and X-ray scattering, dynamic light scattering, differential scanning calorimetry, surface quartz microbalance, nuclear magnetic resonance, confocal fluorescence microscopy, and molecular dynamics simulations. The aim of this "2023 Michèle Auger Award" review work is to provide the reader with an up-to-date overview of this fascinating research field where "ILs meet lipid bilayers (aka biomembranes)," with the aim to boost it further and expand its cross-disciplinary edges towards novel high-impact ideas/applications in pharmacology, drug delivery, biomedicine, and bio-nanotechnology.

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来源期刊
Biophysical reviews
Biophysical reviews Biochemistry, Genetics and Molecular Biology-Biophysics
CiteScore
8.90
自引率
0.00%
发文量
93
期刊介绍: Biophysical Reviews aims to publish critical and timely reviews from key figures in the field of biophysics. The bulk of the reviews that are currently published are from invited authors, but the journal is also open for non-solicited reviews. Interested authors are encouraged to discuss the possibility of contributing a review with the Editor-in-Chief prior to submission. Through publishing reviews on biophysics, the editors of the journal hope to illustrate the great power and potential of physical techniques in the biological sciences, they aim to stimulate the discussion and promote further research and would like to educate and enthuse basic researcher scientists and students of biophysics. Biophysical Reviews covers the entire field of biophysics, generally defined as the science of describing and defining biological phenomenon using the concepts and the techniques of physics. This includes but is not limited by such areas as: - Bioinformatics - Biophysical methods and instrumentation - Medical biophysics - Biosystems - Cell biophysics and organization - Macromolecules: dynamics, structures and interactions - Single molecule biophysics - Membrane biophysics, channels and transportation
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