{"title":"轴向配位金纳米簇为 Fe-N-C 纳米酶量身定制，以增强类似氧化酶的特异性和活性。","authors":"Yameng Xie, Fuli Sun, Kuan Chang, Guang Li, Zhijia Song, Jiayu Huang, Xiqing Cheng, Guilin Zhuang, Qin Kuang","doi":"10.1002/advs.202306911","DOIUrl":null,"url":null,"abstract":"<p>Metal–organic frameworks (MOF) derived nitrogen-doped carbon-supported monodisperse Fe (Fe–N–C) catalysts are intensively studied, but great challenges remain in understanding the relationship between the coordination structure and the performance of Fe–N–C nanozymes. Herein, a novel nanocluster ligand-bridging strategy is proposed for constructing Fe-S<sub>1</sub>N<sub>4</sub> structures with axially coordinated S and Au nanoclusters on ZIF-8 derived Fe–N–C (labeled Au<sub>x</sub>/Fe-S<sub>1</sub>N<sub>4</sub>-C). The axial Au nanoclusters facilitate electron transfer to Fe active sites, utilizing the bridging ligand S as a medium, thereby enhancing the oxygen adsorption capacity of composite nanozymes. Compared to Fe-N-C, Au<sub>x</sub>/Fe-S<sub>1</sub>N<sub>4</sub>-C exhibits high oxidase-like specificity and activity, and holds great potential for detecting acetylcholinesterase activity with a detection limit of 5.1 µU mL<sup>−1</sup>, surpassing most reported nanozymes.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"11 11","pages":""},"PeriodicalIF":14.3000,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.202306911","citationCount":"0","resultStr":"{\"title\":\"Axially Coordinated Gold Nanoclusters Tailoring Fe–N–C Nanozymes for Enhanced Oxidase-Like Specificity and Activity\",\"authors\":\"Yameng Xie, Fuli Sun, Kuan Chang, Guang Li, Zhijia Song, Jiayu Huang, Xiqing Cheng, Guilin Zhuang, Qin Kuang\",\"doi\":\"10.1002/advs.202306911\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Metal–organic frameworks (MOF) derived nitrogen-doped carbon-supported monodisperse Fe (Fe–N–C) catalysts are intensively studied, but great challenges remain in understanding the relationship between the coordination structure and the performance of Fe–N–C nanozymes. Herein, a novel nanocluster ligand-bridging strategy is proposed for constructing Fe-S<sub>1</sub>N<sub>4</sub> structures with axially coordinated S and Au nanoclusters on ZIF-8 derived Fe–N–C (labeled Au<sub>x</sub>/Fe-S<sub>1</sub>N<sub>4</sub>-C). The axial Au nanoclusters facilitate electron transfer to Fe active sites, utilizing the bridging ligand S as a medium, thereby enhancing the oxygen adsorption capacity of composite nanozymes. Compared to Fe-N-C, Au<sub>x</sub>/Fe-S<sub>1</sub>N<sub>4</sub>-C exhibits high oxidase-like specificity and activity, and holds great potential for detecting acetylcholinesterase activity with a detection limit of 5.1 µU mL<sup>−1</sup>, surpassing most reported nanozymes.</p>\",\"PeriodicalId\":117,\"journal\":{\"name\":\"Advanced Science\",\"volume\":\"11 11\",\"pages\":\"\"},\"PeriodicalIF\":14.3000,\"publicationDate\":\"2024-01-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.202306911\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advanced Science\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/advs.202306911\",\"RegionNum\":1,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Science","FirstCategoryId":"88","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/advs.202306911","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
摘要
人们对金属有机框架（MOF）衍生的掺氮碳支撑单分散铁（Fe-N-C）催化剂进行了深入研究，但在理解配位结构与 Fe-N-C 纳米催化剂性能之间的关系方面仍存在巨大挑战。本文提出了一种新型纳米簇配体桥接策略，用于在 ZIF-8 衍生的 Fe-N-C 上构建轴向配位 S 和 Au 纳米簇的 Fe-S1 N4 结构（标记为 Aux /Fe-S1 N4-C）。轴向金纳米团簇利用桥接配体 S 作为媒介，促进电子转移到铁的活性位点，从而提高了复合纳米酶的氧气吸附能力。与 Fe-N-C 相比，Aux /Fe-S1 N4 -C 具有很高的氧化酶特异性和活性，在检测乙酰胆碱酯酶活性方面具有很大的潜力，其检测限为 5.1 µU mL-1，超过了大多数已报道的纳米酶。
Axially Coordinated Gold Nanoclusters Tailoring Fe–N–C Nanozymes for Enhanced Oxidase-Like Specificity and Activity
Metal–organic frameworks (MOF) derived nitrogen-doped carbon-supported monodisperse Fe (Fe–N–C) catalysts are intensively studied, but great challenges remain in understanding the relationship between the coordination structure and the performance of Fe–N–C nanozymes. Herein, a novel nanocluster ligand-bridging strategy is proposed for constructing Fe-S1N4 structures with axially coordinated S and Au nanoclusters on ZIF-8 derived Fe–N–C (labeled Aux/Fe-S1N4-C). The axial Au nanoclusters facilitate electron transfer to Fe active sites, utilizing the bridging ligand S as a medium, thereby enhancing the oxygen adsorption capacity of composite nanozymes. Compared to Fe-N-C, Aux/Fe-S1N4-C exhibits high oxidase-like specificity and activity, and holds great potential for detecting acetylcholinesterase activity with a detection limit of 5.1 µU mL−1, surpassing most reported nanozymes.
期刊介绍：
Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.
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