自评健康状况差与 2 型糖尿病老年人认知能力下降速度加快和小血管疾病增多有关

IF 4.6 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Nadia Ramsingh, Hung-Mo Lin, Yuxia Ouyang, Ramit Ravona-Springer, Abigail Livny, Laili Soleimani, Barbara B. Bendlin, Mery Ben Meir, Anthony Heymann, Mary Sano, Joseph Azuri, Michal Schnaider Beeri
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引用次数: 0

摘要

自评健康(SRH)是不良健康后果和认知能力的预测因素。患有 2 型糖尿病(T2D)的老年人多病缠身,认知障碍也更严重。在本研究中,我们调查了 SRH 与患有 T2D 的老年人认知能力下降和大脑病理学的关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Poor self-rated health is associated with faster cognitive decline and greater small vessel disease in older adults with type 2 diabetes

Poor self-rated health is associated with faster cognitive decline and greater small vessel disease in older adults with type 2 diabetes

Objective

Self-rated health (SRH) is a predictor for poor health outcomes and cognition. Older adults with type 2 diabetes mellitus (T2D) have multi-morbidity and greater cognitive impairment. In the present study we investigated the association of SRH with cognitive decline and brain pathology in older adults with T2D.

Methods

Participants (n = 1122) were from the Israel Diabetes and Cognitive Decline study, and SRH was categorised as low (n = 202), moderate (n = 400) or high (n = 520). Cognition was measured by four cognitive domains: episodic memory, executive functions, language, and attention/working memory. Global cognition was the average of the cognitive domains. Statistical models adjusted for sociodemographic, cardiovascular, and clinical variables. In a randomly selected subsample (n = 230) that had magnetic resonance imaging, we examined relationships between baseline SRH and brain characteristics (white matter hyperintensities [WMHs], hippocampal, and total grey matter [GM] volumes).

Results

Low SRH was associated with a decline in executive functions, which accelerated over time when compared to high SRH (est = −0.0036; p = <0.001). Compared to high SRH, low SRH was associated with a faster decline in global cognition (est = −0.0024; p = 0.009). Low SRH at baseline was associated with higher volumes of WMHs (est = 9.8420; p < 0.0008). SRH was not associated with other cognitive domains, or with hippocampal and total GM.

Conclusions

Low SRH is associated with cognitive decline in T2D older adults and may serve as a risk assessment. WMHs may represent an underlying mechanism.

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来源期刊
Diabetes/Metabolism Research and Reviews
Diabetes/Metabolism Research and Reviews 医学-内分泌学与代谢
CiteScore
17.20
自引率
2.50%
发文量
84
审稿时长
4-8 weeks
期刊介绍: Diabetes/Metabolism Research and Reviews is a premier endocrinology and metabolism journal esteemed by clinicians and researchers alike. Encompassing a wide spectrum of topics including diabetes, endocrinology, metabolism, and obesity, the journal eagerly accepts submissions ranging from clinical studies to basic and translational research, as well as reviews exploring historical progress, controversial issues, and prominent opinions in the field. Join us in advancing knowledge and understanding in the realm of diabetes and metabolism.
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