α-蒎烯对氯胺酮诱导的精神分裂症小鼠模型行为缺陷的神经保护作用:关注氧化应激状态

IF 2 Q3 NEUROSCIENCES
Akbar Hajizadeh Moghaddam , Fatemeh Malekzadeh Estalkhi , Sedigheh Khanjani Jelodar , Tabarek Ahmed Hasan , Soroush Farhadi-Pahnedari , Mohammad Karimian
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引用次数: 0

摘要

精神分裂症(SCZ)是一种严重的神经系统疾病,约占全球人口的 1%。α-蒎烯(α-pinene)是针叶树油(主要是松树)中的一种天然活性单萜,具有抗氧化、抗焦虑和抗抑郁等多种药理特性。本研究以雄性小鼠为研究对象,探讨了α-蒎烯对α-蒎烯诱导的 SCZ 小鼠模型中氧化应激、记忆缺陷、抑郁和焦虑行为的神经保护作用。小鼠被随机分为六组:载体组、对照组、阳性对照组、氯胺酮组、α-蒎烯(50 毫克/千克)组和α-蒎烯(100 毫克/千克)组。用α-蒎烯治疗氯胺酮诱导的SCZ小鼠模型,可显著改善小鼠的抑郁和焦虑行为以及认知障碍。此外,它还能明显提高谷胱甘肽(GSH)水平、总抗氧化能力(TAC)、多巴胺水平、过氧化氢酶(CAT)和超氧化物歧化酶(SOD)活性,同时明显降低丙二醛(MDA)水平。目前的研究证实,α-蒎烯治疗能有效减轻氯胺酮治疗小鼠大脑中的氧化损伤、认知障碍、抑郁和焦虑行为。因此,α-蒎烯治疗是防止氯胺酮诱导的 SCZ 模型小鼠神经行为和神经生化不良影响的有效方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neuroprotective effects of alpha-pinene against behavioral deficits in ketamine-induced mice model of schizophrenia: Focusing on oxidative stress status

Schizophrenia (SCZ) is a profound neurological disorder that affects approximately 1% of the global population. Alpha-pinene (α-pinene) is a natural and active monoterpene found in coniferous tree oil, primarily pine, with diverse pharmacological characteristics, including antioxidative, anxiolytic, and antidepressant properties. This research study delves into the neuroprotective effects of α-pinene on oxidative stress, memory deficits, and depressive and anxiety-like behaviors in a ketamine-induced mice model of SCZ using male mice. The mice were randomly divided into six groups: vehicle, control, positive control, ketamine, α-pinene at 50 mg/kg, and α-pinene at 100 mg/kg. Treatment of the ketamine-induced mice model of SCZ with α-pinene yielded significant improvements in depressive and anxiety-like behaviors and cognitive impairments. Furthermore, it significantly elevated glutathione (GSH) levels, total antioxidant capacity (TAC), dopamine levels, catalase (CAT), and superoxide dismutase (SOD) activities while markedly reducing malondialdehyde (MDA) levels. The current study establishes that α-pinene treatment effectively mitigates oxidative damage, cognitive deficits, and depressive and anxiogenic-like behaviors in the brains of ketamine-treated mice. Therefore, α-pinene treatment is an efficacious approach to forestall the neurobehavioral and neurobiochemical adverse effects of the ketamine-induced SCZ model of mice.

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来源期刊
IBRO Neuroscience Reports
IBRO Neuroscience Reports Neuroscience-Neuroscience (all)
CiteScore
2.80
自引率
0.00%
发文量
99
审稿时长
14 weeks
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