通过病历审核评估内分泌科医生对内源性库欣综合征负担的看法。

IF 3.3 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Pituitary Pub Date : 2024-04-01 Epub Date: 2024-01-08 DOI:10.1007/s11102-023-01371-y
Gabrielle Page-Wilson, Bhagyashree Oak, Abigail Silber, James Meyer, Matthew O'Hara, Eliza B Geer
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引用次数: 0

摘要

目的:本研究从内分泌科医生的角度评估内源性库欣氏综合征(CS)护理模式中尚未满足的需求,包括从患者病历中提取的数据。该研究评估了内分泌专家对疾病负担和治疗原理的看法,以及CS的长期临床负担、CS治疗的耐受性和CS的医疗资源利用情况:方法:采用横断面调查的方式,从经治疗确诊为 CS 的患者中抽取回顾性病历数据,向合格的内分泌科医生收集数据。调查包括一份病例报告表和一份网络问卷,前者用于收集患者病历数据,后者用于收集内分泌医生对疾病负担、CS 治疗方法和治疗属性的看法等从业人员层面的数据:69名内分泌专家从273份CS患者的病历中摘录了数据。患者平均年龄为 46.5 ± 13.4 岁,男女比例为 60:40(女性:男性)。内源性 CS 患者的平均病程为 4.1 年。病历数据显示,尽管接受了多种模式的治疗,但患者仍有较多的合并症和症状,包括疲劳、体重增加和肌肉无力。在评估CS的治疗方法时,内分泌专家将改善与健康相关的生活质量(HRQoL)评为最重要的治疗属性(平均分=7.8;评分标准从1分=完全不重要到9分=非常重要)。手术干预是内分泌专家最满意的治疗方式,但他们一致认为CS患者的治疗需求仍未得到满足:结论:内分泌专家认识到,CS 患者的症状和 HRQoL 负担很高,是一种使人衰弱的疾病,并表示改善 HRQoL 是影响其治疗选择的关键治疗因素。这项研究强调了 CS 患者尚未得到满足的需求。CS 患者的发病率和合并症发生率很高,即使在治疗后也是如此。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A medical chart audit to assess endocrinologist perceptions of the burden of endogenous Cushing's syndrome.

A medical chart audit to assess endocrinologist perceptions of the burden of endogenous Cushing's syndrome.

Purpose: This study was undertaken to assess the unmet needs within the endogenous Cushing's syndrome (CS) care paradigm from the endocrinologist's perspective, including data abstracted from patient charts. The study evaluated endocrinologists' perceptions on burden of illness and treatment rationale along with the long-term clinical burden of CS, tolerability of CS treatments, and healthcare resource utilization for CS.

Methods: Retrospective medical chart data from treated patients with a confirmed diagnosis of CS was abstracted using a cross-sectional survey to collect data from qualified endocrinologists. The survey included a case report form to capture patient medical chart data and a web-enabled questionnaire to capture practitioner-level data pertaining to endocrinologists' perceptions of disease burden, CS treatments, and treatment attributes.

Results: Sixty-nine endocrinologists abstracted data from 273 unique medical charts of patients with CS. Mean patient age was 46.5 ± 13.4 years, with a 60:40 (female:male) gender split. The mean duration of endogenous CS amongst patients was 4.1 years. Chart data indicated that patients experienced a high burden of comorbidities and symptoms, including fatigue, weight gain, and muscle weakness despite multi-modal treatment. When evaluating treatments for CS, endocrinologists rated improvement in health-related quality of life (HRQoL) as the most important treatment attribute (mean score = 7.8; on a scale of 1 = Not at all important to 9 = Extremely important). Surgical intervention was the modality endocrinologists were most satisfied with, but they agreed that there was a significant unmet treatment need for patients with CS.

Conclusion: Endocrinologists recognized that patients with CS suffered from a debilitating condition with a high symptomatic and HRQoL burden and reported that improvement in HRQoL was the key treatment attribute influencing their treatment choices. This study highlights unmet needs for patients with CS. Patients with CS have a high rate of morbidity and comorbidity, even after treatment.

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来源期刊
Pituitary
Pituitary 医学-内分泌学与代谢
CiteScore
7.10
自引率
7.90%
发文量
90
审稿时长
6 months
期刊介绍: Pituitary is an international publication devoted to basic and clinical aspects of the pituitary gland. It is designed to publish original, high quality research in both basic and pituitary function as well as clinical pituitary disease. The journal considers: Biology of Pituitary Tumors Mechanisms of Pituitary Hormone Secretion Regulation of Pituitary Function Prospective Clinical Studies of Pituitary Disease Critical Basic and Clinical Reviews Pituitary is directed at basic investigators, physiologists, clinical adult and pediatric endocrinologists, neurosurgeons and reproductive endocrinologists interested in the broad field of the pituitary and its disorders. The Editorial Board has been drawn from international experts in basic and clinical endocrinology. The journal offers a rapid turnaround time for review of manuscripts, and the high standard of the journal is maintained by a selective peer-review process which aims to publish only the highest quality manuscripts. Pituitary will foster the publication of creative scholarship as it pertains to the pituitary and will provide a forum for basic scientists and clinicians to publish their high quality pituitary-related work.
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