Toll 样受体与变异链球菌：最新综述文章。

IF 2.5 4区医学 Q3 ALLERGY

Allergologia et immunopathologia Pub Date : 2024-01-01 DOI:10.15586/aei.v52i1.935

Fatima Zuhair Muhammad Al-Alawi, Ashraf Kariminik, Elaheh Tajbakhsh

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引用次数: 0

摘要

据报道，收费样受体（TLRs）是识别革兰氏阳性病原体相关分子模式（PAMPs）的主要先天性免疫受体。这些分子能诱导先天性免疫相关分子的表达，而先天性免疫相关分子对抵抗细菌至关重要。变异链球菌（S. mutans）是一种潜在的龋病相关病原体，先天性免疫在抑制其发展和炎症反应进展方面发挥着关键作用。最近，几项研究评估了 TLRs 在抑制变异杆菌和诱导炎症反应方面所起的作用。这篇综述文章讨论了有关 TLRs 所起作用的最新信息及其对变异杆菌的潜在治疗效果。

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Toll-like receptors and Streptococcus mutans: An updated review article.

It has been reported that toll-like receptors (TLRs) are the main innate immune receptors that recognize gram-positive pathogen-associated molecular patterns (PAMPs). The molecules can induce expression of the innate immune-related molecules that are essential against the bacteria. Streptococcus mutans (S. mutans) is a potential caries-associated pathogen, and innate immunity plays a key role in inhibiting its development and the progression of inflammatory responses. Recently, the roles played by TLRs against S. mutans and the induction of inflammatory responses were evaluated by several investigations. This review article discusses updated information regarding the roles played by TLRs and their potential therapeutic effects against S. mutans.

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来源期刊

Allergologia et immunopathologia 医学-过敏

CiteScore

3.70

自引率

0.00%

发文量

131

审稿时长

6-12 weeks

期刊介绍： Founded in 1972 by Professor A. Oehling, Allergologia et Immunopathologia is a forum for those working in the field of pediatric asthma, allergy and immunology. Manuscripts related to clinical, epidemiological and experimental allergy and immunopathology related to childhood will be considered for publication. Allergologia et Immunopathologia is the official journal of the Spanish Society of Pediatric Allergy and Clinical Immunology (SEICAP) and also of the Latin American Society of Immunodeficiencies (LASID). It has and independent international Editorial Committee which submits received papers for peer-reviewing by international experts. The journal accepts original and review articles from all over the world, together with consensus statements from the aforementioned societies. Occasionally, the opinion of an expert on a burning topic is published in the "Point of View" section. Letters to the Editor on previously published papers are welcomed. Allergologia et Immunopathologia publishes 6 issues per year and is included in the major databases such as Pubmed, Scopus, Web of Knowledge, etc.