利用 IBD-AWARE 对炎症性肠病中的 IL-6 和 CRP 进行纵向监测

IF 10.61 Q3 Biochemistry, Genetics and Molecular Biology
Robert P. Hirten , Kai-Chun Lin , Jessica Whang , Sarah Shahub , Nathan K.M. Churcher , Drew Helmus , Sriram Muthukumar , Bruce Sands , Shalini Prasad
{"title":"利用 IBD-AWARE 对炎症性肠病中的 IL-6 和 CRP 进行纵向监测","authors":"Robert P. Hirten ,&nbsp;Kai-Chun Lin ,&nbsp;Jessica Whang ,&nbsp;Sarah Shahub ,&nbsp;Nathan K.M. Churcher ,&nbsp;Drew Helmus ,&nbsp;Sriram Muthukumar ,&nbsp;Bruce Sands ,&nbsp;Shalini Prasad","doi":"10.1016/j.biosx.2023.100435","DOIUrl":null,"url":null,"abstract":"<div><p>There are limitations to monitoring modalities for chronic inflammatory conditions, including inflammatory bowel disease (IBD). Wearable devices are scalable mobile health technology that present an opportunity to monitor markers that have been linked to worsening, chronic inflammatory conditions and enable remote monitoring. In this research article, we evaluate and demonstrate a proof-of-concept wearable device to longitudinally monitor inflammatory and immune markers linked to IBD disease activity in sweat compared to expression in serum. Sixteen participants with an IBD-related hospital admission and a C-reactive protein (CRP) &gt; 5 μg/mL were followed for up to 5 days. The sweat sensing device also known as IBD AWARE was worn to continuously measure CRP and interleukin-6 (IL-6) in the sweat of participants via electrochemical impedance spectroscopy. Serum samples were collected daily. A linear relationship between serum and sweat readings for CRP and IL-6 was demonstrated based on individual linear correlation coefficients. Pooled CRP and IL-6 serum-to-sweat ratios demonstrated improving correlation coefficients as serum cutoffs decreased. Between the first and last day of observation, significant and non-significant trends in serum CRP and IL-6 were observed in the sweat. Comparison of sweat measurements between the subjects with active IBD and 10 healthy subjects distinguished an inflamed and uninflamed state with an AUC of 0.85 (95% CI: 0.68–1.00) and a sensitivity and specificity of 82% and 70% at a CRP cutoff of 938.9 pg/mL. IBD AWARE wearable device holds promise in longitudinally monitoring individuals with IBD and other inflammatory diseases.</p></div>","PeriodicalId":260,"journal":{"name":"Biosensors and Bioelectronics: X","volume":"16 ","pages":"Article 100435"},"PeriodicalIF":10.6100,"publicationDate":"2024-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590137023001383/pdfft?md5=f16ba671db8902adeb961c94e1bafa94&pid=1-s2.0-S2590137023001383-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Longitudinal monitoring of IL-6 and CRP in inflammatory bowel disease using IBD-AWARE\",\"authors\":\"Robert P. Hirten ,&nbsp;Kai-Chun Lin ,&nbsp;Jessica Whang ,&nbsp;Sarah Shahub ,&nbsp;Nathan K.M. Churcher ,&nbsp;Drew Helmus ,&nbsp;Sriram Muthukumar ,&nbsp;Bruce Sands ,&nbsp;Shalini Prasad\",\"doi\":\"10.1016/j.biosx.2023.100435\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>There are limitations to monitoring modalities for chronic inflammatory conditions, including inflammatory bowel disease (IBD). Wearable devices are scalable mobile health technology that present an opportunity to monitor markers that have been linked to worsening, chronic inflammatory conditions and enable remote monitoring. In this research article, we evaluate and demonstrate a proof-of-concept wearable device to longitudinally monitor inflammatory and immune markers linked to IBD disease activity in sweat compared to expression in serum. Sixteen participants with an IBD-related hospital admission and a C-reactive protein (CRP) &gt; 5 μg/mL were followed for up to 5 days. The sweat sensing device also known as IBD AWARE was worn to continuously measure CRP and interleukin-6 (IL-6) in the sweat of participants via electrochemical impedance spectroscopy. Serum samples were collected daily. A linear relationship between serum and sweat readings for CRP and IL-6 was demonstrated based on individual linear correlation coefficients. Pooled CRP and IL-6 serum-to-sweat ratios demonstrated improving correlation coefficients as serum cutoffs decreased. Between the first and last day of observation, significant and non-significant trends in serum CRP and IL-6 were observed in the sweat. Comparison of sweat measurements between the subjects with active IBD and 10 healthy subjects distinguished an inflamed and uninflamed state with an AUC of 0.85 (95% CI: 0.68–1.00) and a sensitivity and specificity of 82% and 70% at a CRP cutoff of 938.9 pg/mL. IBD AWARE wearable device holds promise in longitudinally monitoring individuals with IBD and other inflammatory diseases.</p></div>\",\"PeriodicalId\":260,\"journal\":{\"name\":\"Biosensors and Bioelectronics: X\",\"volume\":\"16 \",\"pages\":\"Article 100435\"},\"PeriodicalIF\":10.6100,\"publicationDate\":\"2024-01-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2590137023001383/pdfft?md5=f16ba671db8902adeb961c94e1bafa94&pid=1-s2.0-S2590137023001383-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biosensors and Bioelectronics: X\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2590137023001383\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Biochemistry, Genetics and Molecular Biology\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biosensors and Bioelectronics: X","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2590137023001383","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0

摘要

包括炎症性肠病(IBD)在内的慢性炎症的监测模式存在局限性。可穿戴设备是一种可扩展的移动医疗技术,为监测与慢性炎症恶化有关的标记物和实现远程监测提供了机会。在这篇研究文章中,我们评估并展示了一种概念验证型可穿戴设备,该设备可纵向监测汗液中与 IBD 疾病活动相关的炎症和免疫标记物,并与血清中的表达进行比较。我们对 16 名入院治疗 IBD 且 C 反应蛋白 (CRP) 为 5 μg/mL 的患者进行了长达 5 天的随访。参与者佩戴汗液传感装置(又称 IBD AWARE),通过电化学阻抗光谱连续测量参与者汗液中的 CRP 和白细胞介素-6(IL-6)。每天收集血清样本。根据单个线性相关系数,CRP 和 IL-6 的血清读数与汗液读数之间存在线性关系。随着血清临界值的降低,汇总的 CRP 和 IL-6 血清与汗液比率的相关系数也在提高。在观察的第一天和最后一天之间,在汗液中观察到血清 CRP 和 IL-6 的显著和不显著趋势。比较活动性 IBD 受试者和 10 名健康受试者的汗液测量值,可以区分炎症和非炎症状态,AUC 为 0.85(95% CI:0.68-1.00),在 CRP 临界值为 938.9 pg/mL 时,灵敏度和特异度分别为 82% 和 70%。IBD AWARE 可穿戴设备有望对患有 IBD 和其他炎症性疾病的患者进行纵向监测。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Longitudinal monitoring of IL-6 and CRP in inflammatory bowel disease using IBD-AWARE

There are limitations to monitoring modalities for chronic inflammatory conditions, including inflammatory bowel disease (IBD). Wearable devices are scalable mobile health technology that present an opportunity to monitor markers that have been linked to worsening, chronic inflammatory conditions and enable remote monitoring. In this research article, we evaluate and demonstrate a proof-of-concept wearable device to longitudinally monitor inflammatory and immune markers linked to IBD disease activity in sweat compared to expression in serum. Sixteen participants with an IBD-related hospital admission and a C-reactive protein (CRP) > 5 μg/mL were followed for up to 5 days. The sweat sensing device also known as IBD AWARE was worn to continuously measure CRP and interleukin-6 (IL-6) in the sweat of participants via electrochemical impedance spectroscopy. Serum samples were collected daily. A linear relationship between serum and sweat readings for CRP and IL-6 was demonstrated based on individual linear correlation coefficients. Pooled CRP and IL-6 serum-to-sweat ratios demonstrated improving correlation coefficients as serum cutoffs decreased. Between the first and last day of observation, significant and non-significant trends in serum CRP and IL-6 were observed in the sweat. Comparison of sweat measurements between the subjects with active IBD and 10 healthy subjects distinguished an inflamed and uninflamed state with an AUC of 0.85 (95% CI: 0.68–1.00) and a sensitivity and specificity of 82% and 70% at a CRP cutoff of 938.9 pg/mL. IBD AWARE wearable device holds promise in longitudinally monitoring individuals with IBD and other inflammatory diseases.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Biosensors and Bioelectronics: X
Biosensors and Bioelectronics: X Biochemistry, Genetics and Molecular Biology-Biophysics
CiteScore
4.60
自引率
0.00%
发文量
166
审稿时长
54 days
期刊介绍: Biosensors and Bioelectronics: X, an open-access companion journal of Biosensors and Bioelectronics, boasts a 2020 Impact Factor of 10.61 (Journal Citation Reports, Clarivate Analytics 2021). Offering authors the opportunity to share their innovative work freely and globally, Biosensors and Bioelectronics: X aims to be a timely and permanent source of information. The journal publishes original research papers, review articles, communications, editorial highlights, perspectives, opinions, and commentaries at the intersection of technological advancements and high-impact applications. Manuscripts submitted to Biosensors and Bioelectronics: X are assessed based on originality and innovation in technology development or applications, aligning with the journal's goal to cater to a broad audience interested in this dynamic field.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信