基于多罗替拉韦的抗逆转录病毒疗法与基于依非韦伦的抗逆转录病毒疗法对埃斯瓦提尼 Matsanjeni 健康中心成年艾滋病病毒感染者体重增加过快的影响：一项回顾性队列研究

IF 2.1 4区医学 Q3 INFECTIOUS DISEASES

AIDS Research and Therapy Pub Date : 2024-01-07 DOI:10.1186/s12981-023-00591-3

Didier M. Mukuna, Tom Decroo, Clara M. Nyapokoto

{"title":"基于多罗替拉韦的抗逆转录病毒疗法与基于依非韦伦的抗逆转录病毒疗法对埃斯瓦提尼 Matsanjeni 健康中心成年艾滋病病毒感染者体重增加过快的影响：一项回顾性队列研究","authors":"Didier M. Mukuna, Tom Decroo, Clara M. Nyapokoto","doi":"10.1186/s12981-023-00591-3","DOIUrl":null,"url":null,"abstract":"There is limited data on dolutegravir (DTG)-associated weight gain from settings with a dual burden of HIV and overnutrition. In Eswatini (at Matsanjeni), among 156 and 160 adult patients on DTG-based and EFV-based antiretroviral therapy (ART), respectively, we studied excessive weight gain (BMI at 24 months ART greater than baseline and ≥25 kg/m2). The median BMI increase in DTG-based patients was 1.09 (IQR:-0.28,3.28) kg/m2 compared to 0.20 (IQR:-0.85,2.18) kg/m2 in EFV-based patients (p value = 0.001). DTG-based ART predicted excessive weight gain (aOR 2.61;95% CI:1.39–4.93). Practitioners should consider DTG-based regimens as one of the risk factors for overweight/obesity.","PeriodicalId":7503,"journal":{"name":"AIDS Research and Therapy","volume":"74 1 1","pages":""},"PeriodicalIF":2.1000,"publicationDate":"2024-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effect of dolutegravir-based versus efavirenz-based antiretroviral therapy on excessive weight gain in adult treatment-naïve HIV patients at Matsanjeni health center, Eswatini: a retrospective cohort study\",\"authors\":\"Didier M. Mukuna, Tom Decroo, Clara M. Nyapokoto\",\"doi\":\"10.1186/s12981-023-00591-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"There is limited data on dolutegravir (DTG)-associated weight gain from settings with a dual burden of HIV and overnutrition. In Eswatini (at Matsanjeni), among 156 and 160 adult patients on DTG-based and EFV-based antiretroviral therapy (ART), respectively, we studied excessive weight gain (BMI at 24 months ART greater than baseline and ≥25 kg/m2). The median BMI increase in DTG-based patients was 1.09 (IQR:-0.28,3.28) kg/m2 compared to 0.20 (IQR:-0.85,2.18) kg/m2 in EFV-based patients (p value = 0.001). DTG-based ART predicted excessive weight gain (aOR 2.61;95% CI:1.39–4.93). Practitioners should consider DTG-based regimens as one of the risk factors for overweight/obesity.\",\"PeriodicalId\":7503,\"journal\":{\"name\":\"AIDS Research and Therapy\",\"volume\":\"74 1 1\",\"pages\":\"\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2024-01-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"AIDS Research and Therapy\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s12981-023-00591-3\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"AIDS Research and Therapy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12981-023-00591-3","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}

引用次数: 0

摘要

在艾滋病和营养过剩双重负担的环境中，有关多鲁曲韦（DTG）相关体重增加的数据非常有限。在埃斯瓦提尼（Matsanjeni），我们对分别接受基于 DTG 和基于 EFV 的抗逆转录病毒疗法（ART）的 156 名和 160 名成年患者进行了体重增加过快（抗逆转录病毒疗法 24 个月时的体重指数大于基线且≥25 kg/m2）的研究。以 DTG 为基础的患者的体重指数增加中位数为 1.09（IQR:-0.28,3.28）kg/m2，而以 EFV 为基础的患者的体重指数增加中位数为 0.20（IQR:-0.85,2.18）kg/m2（P 值 = 0.001）。以 DTG 为基础的抗逆转录病毒疗法会导致体重增加过多（aOR 2.61；95% CI：1.39-4.93）。医生应将基于 DTG 的治疗方案视为超重/肥胖的风险因素之一。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Effect of dolutegravir-based versus efavirenz-based antiretroviral therapy on excessive weight gain in adult treatment-naïve HIV patients at Matsanjeni health center, Eswatini: a retrospective cohort study

There is limited data on dolutegravir (DTG)-associated weight gain from settings with a dual burden of HIV and overnutrition. In Eswatini (at Matsanjeni), among 156 and 160 adult patients on DTG-based and EFV-based antiretroviral therapy (ART), respectively, we studied excessive weight gain (BMI at 24 months ART greater than baseline and ≥25 kg/m2). The median BMI increase in DTG-based patients was 1.09 (IQR:-0.28,3.28) kg/m2 compared to 0.20 (IQR:-0.85,2.18) kg/m2 in EFV-based patients (p value = 0.001). DTG-based ART predicted excessive weight gain (aOR 2.61;95% CI:1.39–4.93). Practitioners should consider DTG-based regimens as one of the risk factors for overweight/obesity.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

AIDS Research and Therapy INFECTIOUS DISEASES-

CiteScore

3.80

自引率

4.50%

发文量

审稿时长

16 weeks

期刊介绍： AIDS Research and Therapy publishes articles on basic science, translational, clinical, social, epidemiological, behavioral and educational sciences articles focused on the treatment and prevention of HIV/AIDS, and the search for the cure. The Journal publishes articles on novel and developing treatment strategies for AIDS as well as on the outcomes of established treatment strategies. Original research articles on animal models that form an essential part of the AIDS treatment research are also considered