人参口服液可提高罗替戈汀贴剂加金刚烷胺对帕金森病的治疗效果

IF 0.4 4区医学 Q4 NUTRITION & DIETETICS

Current Topics in Nutraceutical Research Pub Date : 2023-07-11 DOI:10.37290/ctnr2641-452x.21:411-416

Lei Hu, Chenhao Zhang, Hailin Dai, Chunliang Zhang, Yuejun Yang, Nan Wang, Fengli Zhao

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引用次数: 0

摘要

罗替戈汀是一种非麦角林类多巴胺激动剂，其透皮贴片可用于治疗帕金森病的症状和体征。在这项研究中，我们探讨了人参口服液对罗替戈汀贴剂加金刚烷胺治疗帕金森病疗效的影响。通过对精神行为、日常活动和运动功能的测量，我们计算出了在人参口服液存在的情况下治疗总有效率的升高。虽然人参口服液降低了帕金森病问卷的得分以及血清淀粉样蛋白 A 和白细胞介素-12 的水平，但却增加了载脂蛋白 A1。两组的不良反应发生率没有差异。综上所述，罗替戈汀贴剂联合金刚烷胺和人参口服液治疗帕金森病疗效显著，可有效提高患者的生活质量，减轻临床症状，减少炎症反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Ginseng Oral Liquid Enhances Therapeutic Output of Rotigotin Patch Plus Amantadine in Parkinson’s Disease

Transdermal patches of rotigotine, a dopamine agonist of the non-ergoline class, are used to treat the signs and symptoms of Parkinson’s disease. In this study, we have probed the effect of ginseng oral liquid on the efficacy of the rotigotin patch plus amantadine in treating Parkinson’s disease. Measurements of mental behavior, daily activities, and motor function were used to calculate the total effective rate of the treatment that was elevated in the presence of ginseng oral liquid. While ginseng oral liquid lowered the Parkinson’s Disease Questionnaire scores and levels of serum amyloid A and interleukin-12, it augmented apolipoprotein A1. No difference was seen in the incidence of adverse events between the two groups. To sum up, rotigotin patches in association with amantadine and ginseng oral liquid are effective in treating Parkinson’s disease, which can effectively promote the quality of life of patients, decrease clinical symptoms, and reduce inflammatory reactions.

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来源期刊

Current Topics in Nutraceutical Research 医学-药学

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Current Topics in Nutraceutical Research is an international, interdisciplinary broad-based peer reviewed scientific journal for critical evaluation of research on chemistry, biology and therapeutic applications of nutraceuticals and functional foods. The major goal of this journal is to provide peer reviewed unbiased scientific data to the decision makers in the nutraceutical and food industry to help make informed choices about development of new products. To this end, the journal will publish two types of review articles. First, a review of preclinical research data coming largely from animal, cell culture and other experimental models. Such data will provide basis for future product development and/or human research initiatives. Second, a critical evaluation of current human experimental data to help market and deliver the product for medically proven use. This journal will also serve as a forum for nutritionists, internists, neurologists, psychiatrists, and all those interested in preventive medicine. The common denominator of all of the topic to be covered by the journal must include nutraceuticals and/functional food. The following is an example of some specific areas that may be of interest to the journal. i) Role of vitamins, minerals, antioxidants and phytonutrients on cardiovascular health, cancer, diabetes, ocular health, mental health, men’s health, women’s health, infant nutrition, ii) Role of herbals on human health, iii) Dietary supplements and sleep, iv) Components of diet that may have beneficial effect on human health, v) regulation of apoptosis and cell viability, vi) Isolation and characterization of bioactive components from functional foods, vii) Nutritional genomics, and viii) Nutritional proteomics.