前列腺癌患者血清前列腺特异性抗原与格里森评分/分级组及其组织病理学结果的相关性:一家三级医疗中心的四年回顾性研究

IF 0.1 Q4 MEDICINE, GENERAL & INTERNAL
Ritu Sharma, Megha Bansal, H. Sharma, Nikhilesh Kumar, Vinish, Monika Gupta, Manju Sirohi
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引用次数: 0

摘要

背景:前列腺特异性抗原(PSA前列腺特异性抗原(PSA)已被广泛用作包括前列腺癌在内的各种前列腺病理学的筛查方法。前列腺癌的恶性潜能与诊断时的肿瘤体积有关,而血清 PSA 水平与 Gleason 分级之间的相关性研究仍是前列腺癌最有力的预测指标之一。目的:在一家三级医疗中心对各种肿瘤性前列腺活检组织中的血清 PSA 和 Gleason 评分/组分级进行相关性分析,并研究其组织病理学结果。材料和方法:本研究使用 PSA 作为筛查工具,并对勒克瑙 T. S. Misra 医学院和医院病理科在 2016 年 6 月至 2020 年 7 月的 4 年间接收的各种肿瘤性和非肿瘤性前列腺活检组织的血清 PSA 水平与 Gleason 评分/组别等级进行相关性分析。结果:无前列腺炎的良性前列腺增生症(BPH)病例的平均血清 PSA 值为 1.80 纳克/毫升,有前列腺炎的良性前列腺增生症病例的平均血清 PSA 值为 5.86 纳克/毫升,恶性病例的平均血清 PSA 值为 55.2 纳克/毫升。血清 PSA 值在 0-4 纳克/毫升范围内与良性病变明显相关,超过 20 纳克/毫升则与恶性病变明显相关。最常见的 Gleason 评分是 7 分,II 级组数量最多。恶性肿瘤和前列腺增生发病率最高的年龄组为 60-69 岁。前列腺癌病例(II 级和 III 级组)的 PSA 值明显升高(P < 0.05)。结论PSA 是诊断前列腺肿瘤性和非肿瘤性病变的有效、敏感和早期筛查方法。PSA 值与前列腺癌的格里森评分/分级组明显相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Correlation of serum prostate-specific antigen with gleason's score/grade group in prostate cancers and their histopathological findings: A 4-year retrospective study at a tertiary care center
Background: Prostate-specific antigen (PSA) has been widely used as a screening method in different prostatic pathology including prostate cancer. The malignant potential of prostate cancer is associated with tumor volume at diagnosis and studies of the correlation between serum PSA levels and Gleason's grading which remains one of the most powerful predictors of prostate cancer. Aim: To correlate serum PSA and Gleason's score/Group grade in various neoplastic prostatic biopsies and to study their histopathological findings at a tertiary care center. Materials and Methods: This study uses PSA as a screening tool and to correlate serum PSA level to Gleason scores/group grades in various neoplastic and nonneoplastic prostatic biopsies, received at the Department of Pathology, T. S. Misra Medical College and Hospital, Lucknow during 4 years from June 2016 to July 2020. Results: The mean serum PSA value in benign prostatic hyperplasia (BPH) without prostatitis cases was 1.80 ng/ml and BPH with prostatitis was 5.86 and in malignant cases was 55.2 ng/ml. Serum PSA in the range of 0–4 ng/ml was significantly associated with benign lesions and a value of more than 20 ng/ml was significantly associated with malignant lesions. The most frequent Gleason score was 7 and Grade group II was the highest in number. The highest incidence of malignancies and prostatic hyperplasia occurred among the 60–69 years of age group. PSA values increased significantly (P < 0.05) in prostatic carcinoma cases (Group grade II and III). Conclusion: PSA is a valid, sensitive, and early screening method for the diagnosis of both neoplastic and nonneoplastic lesions of the prostate. PSA values correlated significantly with Gleason's score/grade groups of prostatic carcinoma.
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来源期刊
Journal of the Scientific Society
Journal of the Scientific Society MEDICINE, GENERAL & INTERNAL-
自引率
33.30%
发文量
19
审稿时长
36 weeks
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