Correlation between total phenolic compounds and antidiabetic activity of some traditional Indian herbs

: The current study establishes a correlation between the overall phenolic content and the antidiabetic properties of traditional Indian herbs that are recognised for their effectiveness in managing diabetes. A total of ten medicinal plants were selected for inclusion in the study, with the selection criteria being based on traditional knowledge. The plant components were subjected to extraction using several solvents including water, methanol, ethyl acetate and petroleum ether. The total phenolic content was determined in triplicate for each extract. The antidiabetic activity of ααααα -amylase inhibition was assessed and the obtained results were compared to those of acarbose, which served as the positive control. The findings of the study indicated that the methanol extraction method yielded the greatest quantity of phenolic compounds, with ethyl acetate extraction method producing a somewhat lower amount. The plant species Momordica charantia exhibited the highest concentration of phenolic compounds. The methanolic extract of Momordica charantia exhibited the most significant inhibition of ααααα -amylase, while the methanol extract of Gymnema sylvestre shown a somewhat lower level of inhibition. A significant correlation was observed between the total phenolic content and the inhibitory action of ααααα -amylase.