评估纤维-4 评分与点剪切波弹性成像在监测非酒精性肝病不同阶段纤维化方面的准确性

S. Rasul
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引用次数: 0

摘要

背景非酒精性肝病(NAFLD)的评估是通过测量血液样本中的生化参数来完成的。然而,非侵入性方法近来变得越来越重要。生化参数和根据生物标志物水平对纤维化相关的非酒精性脂肪肝进行分期已成为该领域的既定程序。因此,将非侵入性方法作为非酒精性脂肪肝纤维化分期的一种可比手段尚待确立。 目的比较血清标记物和点剪切波弹性成像在非酒精性脂肪肝纤维化分类及其分期方面的诊断性能。 材料和方法通过实验室检测和点剪切波弹性成像收集数据。根据所得定量数据的交叉分析,比较 FIB-4 指数评分和点剪切波弹性成像对非酒精性脂肪肝纤维化的分期。 结果 FIB4 与年龄、ALT、AST、RBS、AST/ALT、AST/UL AST、APRI、AST/血小板计数和点剪切波弹性成像(PSWE)呈显著正相关。FIB4 与体重、身高、体重指数、谷草转氨酶/谷丙转氨酶、谷草转氨酶/血小板计数呈负相关,且不显著。 结论本研究观察到 FIB-4 与 PSWE 呈正相关。因此,本研究建议将 PSWE 作为一种非侵入性诊断工具,用于对 FIB-4 中级评分的非酒精性脂肪肝患者进行纤维化分期。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
ASSESSING THE ACCURACY OF FIB-4 SCORES TO POINT SHEAR WAVE ELASTOGRAPHY IN MONITORING DIFFERENT STAGES OF FIBROSIS IN NON-ALCOHOLIC LIVER DISEASE
BackgroundNon-alcoholic liver disease (NAFLD) assessment is done by measuring biochemical parameters from blood samples. However, non-invasive methods have gained significance lately. Biochemical parameters and staging of fibrosis-associated NAFLD based on the levels of biomarkers have been established procedures in the field. So, the utilization of non-invasive methods as a comparable means for fibrosis staging in NAFLD has yet to be established. ObjectivesTo compare the diagnostic performance of serum markers to point shear wave elastography for classifying fibrosis in NAFLD and its staging. Materials and MethodsData were collected by laboratory tests and point shear wave elastography. A comparison of FIB-4 indexes scores and point shear wave elastography for the staging of fibrosis in NAFLD was made based on cross-tabulation of the quantitative data obtained. ResultsA positive and significant correlation between FIB4 and age, ALT, AST, RBS, AST/ ALT, AST/ UL AST, APRI, AST/ Platelet count, and point shear wave elastography (PSWE). The correlation was negative and non-significant between FIB4 and Weight, Height, BMI, UL AST, TSB, and Platelet count. ConclusionThe study observed a positive correlation between FIB-4 and PSWE. Thus, the present study proposes the use of PSWE as a non-invasive diagnostic tool in the staging of fibrosis in NAFLD for patients with an intermediate FIB-4 score.
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