更年期与血脂谱的相关性:哈里亚纳邦贾贾尔世界医学科学研究学院的一项研究

Geeta Rustagi, Himanshi Rustagi, Ritu Bawa
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Lipid profiles, including total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and very-low-density lipoprotein cholesterol (VLDL-C), were measured. Data were statistically analyzed using an independent t-test with significance set at p < 0.05. Results: In the study of 126 postmenopausal women, mean lipid profiles demonstrated notable values: total cholesterol (TC) at 191.59±35.78 mg/dl, triglycerides (TG) at 143.44±72.39 mg/dl, high-density lipoprotein cholesterol (HDL-C) at 45.01±9.99 mg/dl, low-density lipoprotein cholesterol (LDL-C) at 116.43±31.79 mg/dl, and very-low-density lipoprotein cholesterol (VLDL-C) at 28.69±14.48 mg/dl. Among 128 premenopausal women, mean lipid profiles were: TC 164±35.03 mg/dl, TG 125.52±65.84 mg/dl, HDL-C 41.66±7.66 mg/dl, LDL-C 96.95±31.78 mg/dl, and VLDL-C 25.10±13.17 mg/dl. 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引用次数: 0

摘要

背景:更年期会诱发荷尔蒙变化,包括雌激素水平下降,从而影响脂质代谢,增加女性罹患心血管疾病的风险。研究目的这项比较观察性研究旨在评估 2020 年 1 月至 2022 年 12 月期间在印度哈里亚纳邦 Jhajjar 世界医学科学研究学院普通健康检查门诊就诊的 35-65 岁女性中绝经与血脂概况之间的相关性。研究方法共纳入 252 名表面健康的妇女,分为绝经前组(126 人)和绝经后组(126 人)。测量血脂概况,包括总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)和极低密度脂蛋白胆固醇(VLDL-C)。数据采用独立 t 检验进行统计分析,显著性以 p < 0.05 为标准。研究结果在对 126 名绝经后妇女进行的研究中,平均血脂曲线显示出显著的数值:总胆固醇 (TC) 为 191.59±35.78 mg/dl,甘油三酯 (TG) 为 143.44±72.39 mg/dl,高密度脂蛋白胆固醇(HDL-C)为 45.01±9.99 mg/dl,低密度脂蛋白胆固醇(LDL-C)为 116.43±31.79 mg/dl,极低密度脂蛋白胆固醇(VLDL-C)为 28.69±14.48 mg/dl。128 名绝经前妇女的平均血脂状况为TC 164±35.03 mg/dl,TG 125.52±65.84 mg/dl,HDL-C 41.66±7.66 mg/dl,LDL-C 96.95±31.78 mg/dl,VLDL-C 25.10±13.17 mg/dl。与绝经前妇女相比,绝经后妇女的总胆固醇(TC)、总胆固醇(TG)、低密度脂蛋白胆固醇(LDL-C)和低密度脂蛋白胆固醇(VLDL-C)的平均水平明显升高,同时心脏风险比(TC/HDL 和 LDL/HDL)也升高。此外,绝经后组的心脏风险比(TC/HDL 和 LDL/HDL)也有所升高。令人惊讶的是,绝经后妇女的 HDL-C 水平也明显较高。结论绝经与血脂谱的不利变化有关,包括总胆固醇、总胆固醇、低密度脂蛋白胆固醇和超低密度脂蛋白胆固醇的升高,以及心脏风险比的升高。然而,绝经后妇女的 HDL-C 水平却出乎意料地高。这些发现强调了在绝经过渡期监测血脂状况以有效解决心血管健康问题的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Correlation of Menopause with Lipid Profile: A Study at World College of Medical Sciences and Research, Jhajjar, Haryana
Background: Menopause induces hormonal changes, including decreased estrogen levels, which can impact lipid metabolism and increase the risk of cardiovascular diseases in women. Objective: This comparative observational study aimed to assess the correlation between menopause and lipid profiles in women aged 35-65 years attending the General Health Check-up OPD at World College of Medical Sciences and Research in Jhajjar, Haryana, India, from January 2020 to December 2022. Methods: A total of 252 apparently healthy women, divided into premenopausal (n=126) and postmenopausal (n=126) groups, were included. Lipid profiles, including total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and very-low-density lipoprotein cholesterol (VLDL-C), were measured. Data were statistically analyzed using an independent t-test with significance set at p < 0.05. Results: In the study of 126 postmenopausal women, mean lipid profiles demonstrated notable values: total cholesterol (TC) at 191.59±35.78 mg/dl, triglycerides (TG) at 143.44±72.39 mg/dl, high-density lipoprotein cholesterol (HDL-C) at 45.01±9.99 mg/dl, low-density lipoprotein cholesterol (LDL-C) at 116.43±31.79 mg/dl, and very-low-density lipoprotein cholesterol (VLDL-C) at 28.69±14.48 mg/dl. Among 128 premenopausal women, mean lipid profiles were: TC 164±35.03 mg/dl, TG 125.52±65.84 mg/dl, HDL-C 41.66±7.66 mg/dl, LDL-C 96.95±31.78 mg/dl, and VLDL-C 25.10±13.17 mg/dl. Postmenopausal women exhibited significantly higher TC, TGs, LDL-C, and VLDL-C, alongside elevated cardiac risk ratios (TC/HDL and LDL/HDL), compared to premenopausal women Postmenopausal women displayed significantly higher mean levels of TC, TG, LDL-C, and VLDL-C compared to premenopausal women. Additionally, cardiac risk ratios, TC/HDL and LDL/HDL, were elevated in the postmenopausal group. Surprisingly, HDL-C levels were also significantly higher in postmenopausal women. Conclusions: Menopause is associated with unfavorable alterations in lipid profiles, including increased TC, TG, LDL-C, and VLDL-C, along with elevated cardiac risk ratios. However, HDL-C levels were unexpectedly higher in postmenopausal women. These findings underscore the importance of monitoring lipid profiles during the menopausal transition to address cardiovascular health concerns effectively.
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