印度尼西亚青少年癌症幸存者的环磷酰胺累积剂量和血清抗穆勒氏管激素水平

IF 0.2 Q4 PEDIATRICS
Sri Mulatsih, S. Ayuandari, Naafi Rizqi Rahmawati, Rizki Oktasari, Agung Dewanto
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引用次数: 0

摘要

背景 随着儿童和青少年癌症发病率和存活率的上升,必须对癌症治疗的长期影响进行研究。环磷酰胺等高风险性腺毒性化疗药物可能会影响卵巢储备功能,从而影响女性青少年的生育能力。抗穆勒氏管激素是评估卵巢储备功能的可靠指标。 目的 评估青少年癌症患者的环磷酰胺累积剂量与血清抗穆勒氏管激素(AMH)水平之间可能存在的相关性。 方法 本横断面研究纳入了 12-18 岁、初潮并接受环磷酰胺治疗的青少年女性癌症患者。我们记录了患者的全部病史(包括月经史),计算了接受环磷酰胺治疗的累积剂量,并测量了血清 AMH 水平。我们进行了相关性检验,以评估环磷酰胺累积剂量与 AMH 水平所代表的卵巢储备功能之间是否存在相关性。 结果 在12名女性青少年癌症患者中,有3人抱怨月经周期紊乱。5名患者的AMH水平较低(<1.5纳克/毫升)。环磷酰胺累积剂量中位数为 1,000 毫克/平方米(范围为 1,000 至 5,250 毫克/平方米)。环磷酰胺累积剂量与血清 AMH 水平呈负相关,但相关性无统计学意义(r=-0.316,P=0.318)。 结论 本研究未能显示环磷酰胺累积剂量与血清 AMH 水平之间存在相关性。建议对接受高风险性腺毒性化疗药物的青少年定期进行生育能力评估,并让生殖团队参与其中。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cumulative cyclophosphamide dose and serum anti-Mullerian hormone levels in adolescent cancer survivors in Indonesia
Background As both the prevalence and survival rates of cancer in children and adolescents has risen, longer-term effects of cancer treatment must be investigated. High-risk gonadotoxic chemotherapeutic agents such as cyclophosphamide may affect the ovarian reserve and impact female adolescent fertility. Anti-Mullerian hormone is a reliable marker to assess ovarian reserve. Objective To assess for a possible correlation between the cumulative dose of cyclophosphamide and serum anti-Mullerian hormone (AMH) levels among adolescent cancer patients. Methods This cross-sectional study included 12-18-year-old adolescent female cancer patients who had experienced menarche and received cyclophosphamide therapy. We recorded the patients’ full history, including menstrual history, computed the cumulative dose of cyclophosphamide received, and measured serum AMH levels. The correlation test was performed to evaluate for a possible correlation between the cumulative dose of cyclophosphamide and ovarian reserve as represented by AMH levels. Results Out of 12 female adolescent cancer patients, three complained of disturbances in their menstrual cycles. Low levels of AMH (<1.5 ng/mL) were noted in five patients. Median cumulative cyclophosphamide dose was 1,000 mg/m2 (range 1,000 to 5,250 mg/m2). Cumulative cyclophosphamide dose was negatively correlated with serum AMH levels, but this correlation was not statistically significant (r=-0.316, P=0.318). Conclusion This study has not been able to show a correlation between cumulative cyclophosphamide dose and serum AMH level. Regular evaluation of fertility and involvement of fertility team is recommended in adolescents receiving high-risk gonadotoxic chemotherapeutic agents.
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来源期刊
CiteScore
0.40
自引率
0.00%
发文量
58
审稿时长
24 weeks
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