术前低白蛋白血症和严重急性营养不良是腹部大手术术后并发症的预后因素:单中心回顾性研究

IF 0.2 Q4 PEDIATRICS
Lestarina Veronica Haloho, N. Nurnaningsih, Endy Paryanto
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引用次数: 0

摘要

背景 低白蛋白血症和营养不良是影响伤口愈合和增加术后感染风险的常见因素。改善白蛋白和术前营养状况有望降低腹部手术后并发症的发生率。 目的 评估低白蛋白血症和术前营养状况不良作为腹部大手术小儿患者术后并发症预后因素的作用。 方法 该回顾性队列研究纳入了2017年1月1日至2021年12月31日期间接受腹部大手术并在萨吉托博士医院儿科重症监护室(PICU)接受治疗的1个月至18岁的儿科患者。主要指标是手术后14天内术后并发症的发生率。 结果 在纳入研究的201名儿科患者中,54.7%为男性。我们观察到,腹部手术后的总体并发症发生率为 21.3%,其中败血症最为常见,占 14.9%。术后并发症平均发生在术后约 10.9 天。多变量分析确定了严重急性营养不良[危险比 (HR) 2.09 (95%CI 1.01 至 4.33);P=0.047]、术前低白蛋白血症>2.5 至 3.0 g/dL [HR 3.64 (95%CI 1.57 至 8.41);P=0.003]、术前低白蛋白血症 ?2.5 g/dL [HR 3.1 (95%CI 1.11 to 8.64); P=0.03] 和年龄小于 1 岁 [HR 2.16 (95%CI 1.09 to 4.11); P=0.026] 是儿童腹部手术后并发症的显著预后因素。 结论 术前严重急性营养不良和术前低白蛋白血症(3 g/dL 以下)是腹部手术小儿患者术后并发症发生的重要预后因素。一岁以下的婴儿发生此类并发症的风险更高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Preoperative hypoalbuminemia and severe acute malnutrition as prognostic factors for postoperative complications in major abdominal surgery: A single-center retrospective study
Background Hypoalbuminemia and malnutrition are common factors that can adversely affect wound healing and increase the risk of postoperative infections. Improvements in albumin and preoperative nutritional status are expected to reduce the incidence of complications following postoperative abdominal surgery. Objective To evaluate the roles of hypoalbuminemia and poor preoperative nutritional status as prognostic factors for postoperative complications in pediatric patients undergoing major abdominal surgery. Methods This retrospective cohort study included pediatric patients aged 1 month to 18 years who underwent major abdominal surgery and were treated in the pediatric intensive care unit (PICU) of Dr. Sardjito Hospital between January 1, 2017 to December 31, 2021. The primary was the incidence of postoperative complications within 14 days after the surgical procedure. Results Out of the 201 pediatric patients included in the study, 54.7% were male. We observed an overall complication rate of 21.3% following abdominal surgery, with sepsis as the most frequent, affecting 14.9% of the cases. On average, postoperative complications occurred approximately 10.9 days after surgery. Multivariate analysis identified severe acute malnutrition [hazard ratio (HR) 2.09 (95%CI 1.01 to 4.33); P=0.047], preoperative hypoalbuminemia of >2.5 to 3.0 g/dL [HR 3.64 (95%CI 1.57 to 8.41); P=0.003], preoperative hypoalbuminemia ?2.5 g/dL [HR 3.1 (95%CI 1.11 to 8.64); P=0.03], and age <1 year [HR 2.16 (95%CI 1.09 to 4.11); P=0.026] as significant prognostic factors for post-abdominal surgery complications in children. Conclusion Preoperative severe acute malnutrition and preoperative hypoalbuminemia of ?3 g/dL are significant prognostic factors for the occurrence of postoperative complications in pediatric patients undergoing abdominal surgery. Infants less than one year of age are at increased risk of such complications.
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CiteScore
0.40
自引率
0.00%
发文量
58
审稿时长
24 weeks
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