Intravascular Proliferation: A Case Report of Intravascular Large B Cell Lymphoma Arising within a Glioblastoma, IDH Wild Type

A synchronous multiple primary tumors is a second tumor that occurs within two months of identification of the first primary cancer. Collision tumors is the definition given to two synchronous tumors in the same organ whereby distinct borders between the two primary tumors are maintained. The occurrence of collision tumors is a very rare phenomenon. Here, we describe a case of an 82-year-old woman who presented with approximately one month’s duration of neurologic deficits. Magnetic resonance imaging (MRI) revealed a left parietal lobe lesion which was radiographically concerning for a high-grade glioma. Following surgical resection microscopic examination of the mass revealed high-grade glioma with synchronous malignant lymphoma involving tumor vasculature, consistent with a collision of glioblastoma, IDH-wildtype, and intravascular large B cell lymphoma. To our knowledge, this represents the first reported case of a collision tumor involving these two entities.