从委内瑞拉巴里纳斯社区成年患者中分离出的耐多药和广泛耐抗菌性尿路病原体。

Poema Salazar, María Araque
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摘要

本研究旨在确定2022年从委内瑞拉巴里纳斯市成年患者体内分离出的多重耐药(MDR)和广泛耐药(XDR)尿路病原体的频率。在巴里纳斯临床微生物实验室就诊的 1019 名患者的尿液培养结果中,有 337 人(33.07%)符合纳入标准。尿液微生物处理采用常规方法。采用标准化表型方法进行了抗菌药物敏感性测试和广谱β-内酰胺酶测定。根据国际标准对 MDR 和 XDR 菌株进行了分类。数据通过描述性统计和频率分析进行处理。在分析的 337 份尿培养物中,女性患者占 70.92%,年龄在 31 岁至 60 岁之间的患者最多。在鉴定出的尿路病原体中,93.17%为肠杆菌科,其中大肠埃希菌占 87.54%,其次是绿脓杆菌(2.67%)和粪肠球菌(1.48%)。在大肠杆菌菌株中,87.12%的菌株对至少一种抗生素产生耐药性,其中 46.78%的菌株产生 MDR,5.42%的菌株产生 XDR。总的来说,在已发现的尿路病原体中,超过一半的病原体具有 MDR 或 XDR 表型。研究结果表明,除了开展合理使用抗生素的宣传活动和对该地区流行的多重耐药菌株进行流行病学监测外,还需要在当地开展研究,以改进尿路感染的经验疗法和靶向疗法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Uropatógenos multirresistentes y con resistencia extendida a los antimicrobianos aislados en pacientes adultos de la comunidad de Barinas, Venezuela.
This study aimed to determine the frequency of multidrug-resis-tant (MDR) and extensively drug-resistant (XDR) uropathogens isolated from adult patients in Barinas City, Venezuela, in 2022. Of 1019 urine cultures from patients who attended the Barinas Clinical Microbiological Laboratory, 337 (33.07%) were selected according to inclusion criteria. The microbiological processing of urine was carried out through conventional methods. Antimicro-bial susceptibility tests and extended-spectrum beta-lactamase determination were performed using standardized phenotypic methods. The classification of MDR and XDR strains was conducted according to international criteria. Data were processed through descriptive statistics and frequency analysis. Of 337 urine cultures analyzed, 70.92% corresponded to female patients, and the age groups between 31 and 60 years were the most frequent. Of the uropathogens identified, 93.17% were represented by Enterobacterales, where Escherichia coli stood out with 87.54%, followed by Pseudomonasaeruginosa (2.67%) and Enterococcus faecalis (1.48%). Of the E. coli strains, 87.12% presented resis-tance to at least one antibiotic, with 46.78% MDR and 5.42% XDR. In general, more than half of the uropathogens identified were distributed either as MDR or XDR phenotypes. The results show the need to develop local research to im-prove empirical and targeted therapies in urinary tract infections, in addition to awareness actions for the rational use of antibiotics and epidemiological surveillance of multiresistant strains circulating in the region.
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