精氨酸在肝癌中的代谢信号作用

Life metabolism Pub Date : 2023-11-27 DOI:10.1093/lifemeta/load046

David Sokolov, Lucas B Sullivan

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引用次数: 0

摘要

除了在生物合成途径中的典型作用外，代谢物还可能是致癌信号转导的积极参与者，但我们对这些信号转导机制的了解还不全面。在最近发表于《细胞》（Cell）的一篇文章中，Mossmann 及其同事发现肝细胞癌（HCC）中积累的精氨酸具有新的信号作用，它由 RNA 剪接因子和转录修饰因子 RNA 结合蛋白 39 (RBM39) 介导。

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A metabolic signaling role for arginine in liver cancer

In addition to their canonical roles in biosynthetic pathways, metabolites can be active participants in oncogenic signaling, but our understanding of these signaling mechanisms is incomplete. In a recent article published in Cell, Mossmann and colleagues find a novel signaling role for accumulated arginine in hepatocellular carcinoma (HCC), mediated by the RNA splicing factor and transcriptional modifier RNA-binding protein 39 (RBM39).

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来源期刊

Life metabolism

CiteScore

1.10

自引率

0.00%

发文量