一种新型稳定性指示紫外光谱法同时测定阿折地平和氯塞酮的纯品及药物剂型

Q4 Pharmacology, Toxicology and Pharmaceutics
Swapna A. Surendran, Haribabu Y., S. V. Kutty, Sreelekha P. Pavithran, Niranjana C. Muralidharan
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引用次数: 0

摘要

本研究开发了一种准确、精确、简便的稳定性指示紫外光谱技术,通过吸光度校正法同时定量阿折地平和氯沙酮的总量和组合。该方法使用乙醇(99.9%)作为溶剂。氯塞酮的检测波长为 275 nm,阿折地平的检测波长为 345 nm。该方法的灵敏度、线性、重现性、准确性、坚固性和稳健性均得到了验证。阿折地平在 3.2-80 µg mL-1 浓度范围内符合比尔-朗伯斯定律,氯塞酮在 5-125 µg mL-1 浓度范围内符合比尔-朗伯斯定律。阿折地平的检测限为 1.74 µg mL-1,氯塞酮的检测限为 2.376 µg mL-1。阿折地平的定量限为 5.272 µg mL-1,而氯塞酮的定量限为 7.2 µg mL-1。进行了加速稳定性研究。在酸、碱、潮湿、高温和氧化环境下,阿折地平和氯塞酮显示出不同的降解特性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A NOVEL STABILITY INDICATING UV SPECTROSCOPIC METHOD FOR SIMULTANEOUS ESTIMATION OF AZELNIDIPINE AND CHLORTHALIDONE IN ITS PURE AND PHARMACEUTICAL DOSAGE FORM
An accurate, precise and simple stability indicating ultraviolet spectroscopic technique was developed to quantify azelnidipine and chlorthalidone, simultaneously was bulk and in combination by absorbance correction method. Ethanol (99.9 %) is used as the solvent in the method. The detection wavelength was found to be 275 nm for chlorthalidone, and 345 nm for azelnidipine. The methodology was validated concerning sensitivity, linearity, reproducibility, accuracy, ruggedness and robustness. Beer-Lamberts law was obeyed in the concentration from 3.2–80 µg mL-1 in case of azelnidipine and 5-125 µg mL-1 in case of chlorthalidone. Detection limits were obtained as 1.74 µg mL-1 for azelnidipine and 2.376 µg mL-1 for chlorthalidone. For azelnidipine, quantification limit was 5.272 µg mL-1, while for chlorthalidone it was 7.2 µg mL-1. Accelerated stability studies were carried out. Azelnidipine and chlorthalidone showed different degradation characteristics under acid, alkali, humidity, heats, and oxidized environment.
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来源期刊
INDIAN DRUGS
INDIAN DRUGS Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
0.30
自引率
0.00%
发文量
98
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