以网络药理学为基础，探索百日草治疗卡铂所致毒性的机制

Q4 Pharmacology, Toxicology and Pharmaceutics

INDIAN DRUGS Pub Date : 2023-11-28 DOI:10.53879/id.60.11.13955

Arpita Chakraborty, R. S. Parveen, Sangita Kamath, Veena Nayak, Suchetha P. Kumar, V. Belle

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引用次数: 0

摘要

Hygrophila auriculata 是一种用于治疗多种疾病的传统草药，其作用机制尚不清楚。本研究旨在检测其对 Wistar 大鼠肾毒性和肝毒性的疗效，并通过网络药理学分析解释其作用机制。24 只大鼠分为 4 组（n=6）。在进行基线血液检查后，第 1 组在第 13 天接受生理盐水治疗，第 2-4 组接受卡铂治疗，第 3、4 组接受不同强度的枳实治疗（第 15 至 30 天）。我们筛选了枳实的活性成分和靶标，并使用 Cytoscape 软件创建了整体网络。我们初步预测了枳实在治疗卡铂引起的肝毒性和肾毒性方面的主要活性成分、靶点和信号通路，这为枳实在临床上应用于治疗卡铂引起的毒性铺平了道路。

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EXPLORATION OF MECHANISM OF HYGROPHILA AURICULATA TO TREAT CARBOPLATIN INDUCED TOXICITIES BUILT ON NETWORK PHARMACOLOGY

Hygrophila auriculata is a traditional herb used for several ailments, with an unclear mechanism of action. The present study aimed to detect its efficacy on nephrotoxicity and hepatotoxicity in Wistar rats followed by network pharmacology analysis to explain its mechanism of action. 24 rats were divided into 4 groups (n=6). After baseline blood investigations, group 1 was treated with normal saline on 13th day, groups 2-4 with carboplatin, groups 3, 4 with different strengths of H. auriculata (day 15 to 30). The active components along with targets of H. auriculata were screened and overall network was created using Cytoscape software. We made preliminary predictions about the major active components, targets along with signalling pathways of H. auriculata to treat carboplatin induced hepatotoxicity and nephrotoxicity, which could pave way for clinical application of H. auriculata against carboplatin induced toxicities.

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来源期刊

INDIAN DRUGS Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

0.30

自引率

0.00%

发文量