用于透皮给药的常压等离子体的最新进展

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-11-28 DOI:10.1088/2058-6272/ad1044

L. Nie, Dawei Liu, He Cheng, Feng Zhao, Xinpei Lu

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引用次数: 0

摘要

与传统方法相比，等离子体增强透皮给药（TDD）具有应用无痛、皮肤损伤小、渗透性恢复快等优点。本综述简明扼要地总结了传统的透皮给药方法，随后对等离子体增强透皮给药的当前先进水平进行了全面考察。这包括分析等离子体对 HaCaT 人类角质细胞的影响、体内/体外研究以及等离子体辅助 TDD 的临床研究。此外，综述还探讨了血浆对皮肤物理特性的影响，如微孔形成、经表皮失水（TEWL）、角质层（SC）分子结构和皮肤抵抗力。此外，它还讨论了等离子体增强 TDD 中各种反应剂的参与情况，包括电场、带电粒子、紫外线/紫外辐射、热量和反应物。最后，本综述简要讨论了等离子体治疗后皮肤的时间行为、安全考虑因素以及等离子体增强 TDD 的潜在风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The state-of-the-art of atmospheric pressure plasma for transdermal drug delivery

Plasma-enhanced transdermal drug delivery (TDD) presents advantages over traditional methods, including painless application, minimal skin damage, and rapid recovery of permeability. To harness its clinical potential, factors related to plasma's unique properties, such as reactive species and electric fields, must be carefully considered.This review provides a concise summary of conventional TDD methods and subsequently offers a comprehensive examination of the current state-of-the-art in plasma-enhanced TDD. This includes an analysis of the impact of plasma on HaCaT human keratinocyte cells, ex vivo/in vivo studies, and clinical research on plasma-assisted TDD. Moreover, the review explores the effects of plasma on skin physical characteristics such as microhole formation, transepidermal water loss (TEWL), molecular structure of the stratum corneum (SC), and skin resistance. Additionally, it discusses the involvement of various reactive agents in plasma-enhanced TDD, encompassing electric fields, charged particles, UV/VUV radiation, heat, and reactive species. Lastly, the review briefly addresses the temporal behavior of the skin after plasma treatment, safety considerations, and potential risks associated with plasma-enhanced TDD.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.