从药典规定的蔷薇科植物原料中提取糖浆成分的开发和质量指标的确定

N. N.V., Nesterova O.V., Maruev A.L.
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引用次数: 0

摘要

俄罗斯联邦国家药典》收录的植物中,蔷薇科植物的数量最多。然而,在国内医药市场上,以这种植物原料为基础的植物制剂数量却不多。考虑到糖浆剂的药用形式越来越受欢迎,作者进行了一项研究,旨在开发用山姜子(Sanguisorbae officinalis rhizomata et radices)根茎和根生产糖浆剂的成分和技术、的根茎(Potentillae erectae rhizomata)、野草莓叶(Fragariae vescae folia)、旱金莲果(Aroniae melanocarpae sicco fructus)、花楸果(Sorbi aucupariae fructus)、玫瑰果(Rosae fructus)、樱桃果(Padi avii fructus)。 糖浆是通过在成分中使用液体提取物的技术获得的,提取物的获得符合 OFS.1.4.1.0021.15 提取物的要求。对获得的所有糖浆进行了质量指标测定:密度、pH 值、折射率、微生物频率。为了确定所开发糖浆中生物活性物质的定量含量,作者采用了端对端标准化原则,包括使用与最初药用植物原料标准化相同的质量控制方法。 对含有药用血吸虫根茎和根、拉普查特卡根茎和樱桃果的糖浆进行了单宁酸总含量测定,对秋海棠果糖浆进行了花青素总含量测定,对花楸果和玫瑰果糖浆进行了花青素总含量测定,对抗坏血酸含量进行了测定,对草莓叶糖浆进行了芦丁类黄酮总含量测定。根据所进行研究的结果,建议了所研究形式中活性物质的含量标准。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
DEVELOPMENT OF COMPOSITION AND DETERMINATION OF QUALITY INDICATORS OF SYRUPS WITH EXTRACTS FROM RAW MATERIALS OF PHARMACOPOEIA PLANTS OF THE ROSACEAE FAMILY
The largest number of plant species included in the State Pharmacopoeia of the Russian Federation belong to the Rosaceae family. However, the number of phytopreparations based on this plant raw material in the domestic pharmaceutical market is not so diverse. Taking into account the growing popularity of the medicinal form of syrups, the authors conducted a study aimed at developing the composition and technology for producing syrups with rhizomes and roots of Sanguisorba (Sanguisorbae officinalis rhizomata et radices), rhizomes of Potentilla (Potentillae erectae rhizomata), leaves of wild strawberries (Fragariae vescae folia), fruits of aronia (dry) (Aroniae melanocarpae sicco fructus), rowan fruits (Sorbi aucupariae fructus), rosehip fruits (Rosae fructus), cherry fruits (Padi avii fructus). Syrups were obtained using a technology using liquid extracts in the composition, which were obtained in accordance with the requirements of the OFS.1.4.1.0021.15 Extracts. For all the syrups obtained, quality indicators were determined: density, pH, refractive index, microbiological frequency. To determine the quantitative content of biologically active substances in the developed syrups, the authors used the principle of end-to-end standardization, involving the use of the same quality control methods used in the standardization of the initial medicinal plant raw materials. The total content of tannins was determined for syrups with rhizomes and roots of medicinal hemophlebus, rhizomes of lapchatka, cherry fruits, the total content of anthocyanins was determined for the syrup of aronia fruits, the total content of anthocyanins was determined for the syrups of rowan and rosehip fruits, the content of ascorbic acid was determined and for strawberry leaf syrup the total content of flavonoids in terms of rutin. According to the results of the conducted studies, the norms of the content of active substances in the studied forms were recommended.
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