{"title":"开发含有大麻籽提取物的多组分栓剂的成分、技术和测试","authors":"S. A.I., N. E.B.","doi":"10.26787/nydha-2686-6838-2023-25-11-49-56","DOIUrl":null,"url":null,"abstract":"Hemorrhoids are one of the most common pathologies among rectal diseases, which most often affects residents of large cities around the world. This fact is explained primarily by the fact that the development of hemorrhoids is facilitated by a sedentary lifestyle of the urban population, bad habits, irregular and unbalanced nutrition, and abuse of fast-food products. The most effective way to treat hemorrhoids is surgery. However, drug therapy is no less important, both at the stage of conservative treatment and in the postoperative period. Most often, hormonal and antibacterial drugs are used to treat hemorrhoids. However, as medical practice shows, their use does not always provide a long-lasting and sustainable antihemorrhoidal effect, and is also characterized by a number of side effects associated with the possibility of systemic absorption of the active components of the drugs. In this regard, the search and development of new safe and effective drugs for the treatment and prevention of exacerbations of hemorrhoids is an urgent task of modern pharmaceutical science. When designing drugs for the treatment of hemorrhoids, it is necessary to take into account the combined clinical picture of this disease, including such manifestations as swelling, inflammation, pain, itching and burning in the rectal area. Thus, it seems appropriate to create a multifunctional antihemorrhoidal drug, which includes components of anti-inflammatory, antimicrobial and anesthetic action. It is possible to ensure such a rational combination by combining synthetic drugs and complexes of biologically active substances of plant origin One of the compositions suitable for the development of an antihemorrhoidal drug is, in our opinion, the combined presence of benzocaine and dry herb extract. Benzocaine is well known as an affordable, effective and safe local anesthetic used for local pain relief. Hemp sapling herb, in turn, is often used in folk medicine as a wound-healing, anti-inflammatory, antimicrobial, decongestant for the treatment of bruises, burns, infected wounds and ulcers of various etiologies. The most rational form for the combination of benzocaine and dry sapling herb extract proposed above seems to be suppositories. In this regard, the purpose of this study was to develop the composition, technology and testing of anti-hemorrhoidal suppositories from the sapling grass with dry extract and benzocaine. It has been established that the developed recipe for rectal suppositories on a hydrophilic basis containing polyethylene oxide 400 and 1500 is distinguished by the necessary technological properties, high bioavailability and meets the requirements of the State Pharmacopoeia of the Russian Federation XV edition.","PeriodicalId":263577,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":"674 ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"DEVELOPMENT OF COMPOSITION, TECHNOLOGY AND TESTING OF POLYCOMPONENT SUPPOSITORIES WITH HEMP SEEDLING EXTRACT\",\"authors\":\"S. A.I., N. E.B.\",\"doi\":\"10.26787/nydha-2686-6838-2023-25-11-49-56\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Hemorrhoids are one of the most common pathologies among rectal diseases, which most often affects residents of large cities around the world. This fact is explained primarily by the fact that the development of hemorrhoids is facilitated by a sedentary lifestyle of the urban population, bad habits, irregular and unbalanced nutrition, and abuse of fast-food products. The most effective way to treat hemorrhoids is surgery. However, drug therapy is no less important, both at the stage of conservative treatment and in the postoperative period. Most often, hormonal and antibacterial drugs are used to treat hemorrhoids. However, as medical practice shows, their use does not always provide a long-lasting and sustainable antihemorrhoidal effect, and is also characterized by a number of side effects associated with the possibility of systemic absorption of the active components of the drugs. In this regard, the search and development of new safe and effective drugs for the treatment and prevention of exacerbations of hemorrhoids is an urgent task of modern pharmaceutical science. When designing drugs for the treatment of hemorrhoids, it is necessary to take into account the combined clinical picture of this disease, including such manifestations as swelling, inflammation, pain, itching and burning in the rectal area. Thus, it seems appropriate to create a multifunctional antihemorrhoidal drug, which includes components of anti-inflammatory, antimicrobial and anesthetic action. It is possible to ensure such a rational combination by combining synthetic drugs and complexes of biologically active substances of plant origin One of the compositions suitable for the development of an antihemorrhoidal drug is, in our opinion, the combined presence of benzocaine and dry herb extract. Benzocaine is well known as an affordable, effective and safe local anesthetic used for local pain relief. Hemp sapling herb, in turn, is often used in folk medicine as a wound-healing, anti-inflammatory, antimicrobial, decongestant for the treatment of bruises, burns, infected wounds and ulcers of various etiologies. The most rational form for the combination of benzocaine and dry sapling herb extract proposed above seems to be suppositories. In this regard, the purpose of this study was to develop the composition, technology and testing of anti-hemorrhoidal suppositories from the sapling grass with dry extract and benzocaine. It has been established that the developed recipe for rectal suppositories on a hydrophilic basis containing polyethylene oxide 400 and 1500 is distinguished by the necessary technological properties, high bioavailability and meets the requirements of the State Pharmacopoeia of the Russian Federation XV edition.\",\"PeriodicalId\":263577,\"journal\":{\"name\":\"\\\"Medical & pharmaceutical journal \\\"Pulse\\\"\",\"volume\":\"674 \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-11-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"\\\"Medical & pharmaceutical journal \\\"Pulse\\\"\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.26787/nydha-2686-6838-2023-25-11-49-56\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"\"Medical & pharmaceutical journal \"Pulse\"","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.26787/nydha-2686-6838-2023-25-11-49-56","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
痔疮是直肠疾病中最常见的病症之一,世界上大城市的居民最常患痔疮。这一事实的主要原因是,城市居民久坐不动的生活方式、不良的生活习惯、不规律和不均衡的营养以及快餐产品的滥用都会促进痔疮的发展。治疗痔疮最有效的方法是手术。然而,无论是在保守治疗阶段还是在术后,药物治疗也同样重要。治疗痔疮最常用的是激素和抗菌药物。然而,医学实践表明,使用这些药物并不总能产生持久的、可持续的抗痔疮效果,而且由于药物的活性成分可能被全身吸收,还会产生一些副作用。因此,寻找和开发安全有效的新药来治疗和预防痔疮恶化是现代制药科学的一项紧迫任务。在设计治疗痔疮的药物时,有必要考虑到这种疾病的综合临床表现,包括直肠部位的肿胀、炎症、疼痛、瘙痒和灼热等表现。因此,似乎应该研制一种多功能抗痔疮药物,其中包括消炎、抗菌和麻醉作用成分。通过将合成药物和植物来源的生物活性物质复合物结合在一起,可以确保这种合理的组合。 我们认为,适合开发止血药的组合物之一是苯佐卡因和干草提取物的结合。众所周知,苯佐卡因是一种经济、有效、安全的局部麻醉剂,可用于局部止痛。而大麻树苗草在民间医学中常被用作伤口愈合剂、消炎剂、抗菌剂和减充血剂,用于治疗各种病因引起的跌打损伤、烧伤、感染伤口和溃疡。上文提出的苯佐卡因和干树苗草提取物的最合理组合形式似乎是栓剂。因此,本研究的目的是开发树苗草干提取物和苯佐卡因抗痔疮栓剂的成分、技术和测试。研究结果表明,所开发的含有聚氧化乙烯 400 和 1500 的亲水性直肠栓剂配方具有必要的技术特性和高生物利用率,符合《俄罗斯联邦国家药典》第 XV 版的要求。
DEVELOPMENT OF COMPOSITION, TECHNOLOGY AND TESTING OF POLYCOMPONENT SUPPOSITORIES WITH HEMP SEEDLING EXTRACT
Hemorrhoids are one of the most common pathologies among rectal diseases, which most often affects residents of large cities around the world. This fact is explained primarily by the fact that the development of hemorrhoids is facilitated by a sedentary lifestyle of the urban population, bad habits, irregular and unbalanced nutrition, and abuse of fast-food products. The most effective way to treat hemorrhoids is surgery. However, drug therapy is no less important, both at the stage of conservative treatment and in the postoperative period. Most often, hormonal and antibacterial drugs are used to treat hemorrhoids. However, as medical practice shows, their use does not always provide a long-lasting and sustainable antihemorrhoidal effect, and is also characterized by a number of side effects associated with the possibility of systemic absorption of the active components of the drugs. In this regard, the search and development of new safe and effective drugs for the treatment and prevention of exacerbations of hemorrhoids is an urgent task of modern pharmaceutical science. When designing drugs for the treatment of hemorrhoids, it is necessary to take into account the combined clinical picture of this disease, including such manifestations as swelling, inflammation, pain, itching and burning in the rectal area. Thus, it seems appropriate to create a multifunctional antihemorrhoidal drug, which includes components of anti-inflammatory, antimicrobial and anesthetic action. It is possible to ensure such a rational combination by combining synthetic drugs and complexes of biologically active substances of plant origin One of the compositions suitable for the development of an antihemorrhoidal drug is, in our opinion, the combined presence of benzocaine and dry herb extract. Benzocaine is well known as an affordable, effective and safe local anesthetic used for local pain relief. Hemp sapling herb, in turn, is often used in folk medicine as a wound-healing, anti-inflammatory, antimicrobial, decongestant for the treatment of bruises, burns, infected wounds and ulcers of various etiologies. The most rational form for the combination of benzocaine and dry sapling herb extract proposed above seems to be suppositories. In this regard, the purpose of this study was to develop the composition, technology and testing of anti-hemorrhoidal suppositories from the sapling grass with dry extract and benzocaine. It has been established that the developed recipe for rectal suppositories on a hydrophilic basis containing polyethylene oxide 400 and 1500 is distinguished by the necessary technological properties, high bioavailability and meets the requirements of the State Pharmacopoeia of the Russian Federation XV edition.